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Although polyacrylic acid (PAA) increased compressive strength and Young's modulus of the cement, it could cause poor apatite phase formation, a prolonged setting time, and a lower degradation rate. Consequently, bioactive glass (BG) was added to PAA\/cement to improve its physical properties, such as compressive strength, Young's modulus, setting time, and degradation. For in vitro testing, HObs viability was assessed under two culture systems with cement\u2010preconditioned medium (indirect) and with cement (direct). HObs viability was examined in direct contact with cements treated by different prewashing conditions. HObs presented a more well spread morphology on cement soaked in medium overnight, as compared to other cements with no treatment and washing in PBS. In addition, the proliferation, differentiation, and total collagen production of both HObs and MSCs adhered to the cement were detected. Cells showed excellent proliferation on PAA\/cement and PAA\/BG\/cement. Furthermore, the higher released Si ion and lower acidosis of PAA\/BG\/cement\u2010conditioned medium resulted in an increase in osteogenic differentiation (HObs and MSCs) and enhanced collagen production (HObs in osteogenic medium and MSCs in control medium). Therefore, our findings suggest that BG incorporated PAA\/apatite\/\u03b2\u2010TCP cement could be a promising formula for bone repair applications.<\/jats:p>","DOI":"10.1002\/jbm.a.37542","type":"journal-article","created":{"date-parts":[[2023,4,3]],"date-time":"2023-04-03T11:57:05Z","timestamp":1680523025000},"page":"1406-1422","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Primary human osteoblast and mesenchymal stem cell responses to apatite\/tricalcium phosphate bone cement modified with polyacrylic acid and bioactive glass"],"prefix":"10.1002","volume":"111","author":[{"given":"Paritat","family":"Thaitalay","sequence":"first","affiliation":[{"name":"School of Ceramic Engineering Institute of Engineering, Suranaree University of Technology  111 University Avenue, Muang District Nakhon Ratchasima 3000 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