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The vulnerable population reliant on catheters post\u2010surgery for food and fluid intake, blood transfusion, or urinary incontinence or retention is susceptible to hospital\u2010acquired infection originating from the very catheter. Bacterial adhesion on catheters can take place during the insertion or over time when catheters are used for an extended period. Nitric oxide\u2010releasing materials have shown promise in exhibiting antibacterial properties without the risk of antibacterial resistance which can be an issue with conventional antibiotics. In this study, 1, 5, and 10\u2009wt % selenium (Se) and 10\u2009wt %\u2009<jats:italic>S<\/jats:italic>\u2010nitrosoglutathione (GSNO)\u2010incorporated catheters were prepared through a layer\u2010by\u2010layer dip\u2010coating method to demonstrate NO\u2010releasing and NO\u2010generating capability of the catheters. The presence of Se on the catheter interface resulted in a 5 times higher NO flux in 10% Se\u2010GSNO catheter through catalytic NO generation. A physiological level of NO release was observed from 10% Se\u2010GSNO catheters for 5\u2009d, along with an enhanced NO generation via the catalytic activity as Se was able to increase NO availability. The catheters were also found to be compatible and stable when subjected to sterilization and storage, even at room temperature. Additionally, the catheters showed a 97.02% and 93.24% reduction in the adhesion of clinically relevant strains of <jats:italic>Escherichia coli<\/jats:italic> and <jats:italic>Staphylococcus aureus<\/jats:italic>, respectively. Cytocompatibility testing of the catheter with 3T3 mouse fibroblast cells supports the material's biocompatibility. These findings from the study establish the proposed catheter as a prospective antibacterial material that can be translated into a clinical setting to combat catheter\u2010related infections.<\/jats:p>","DOI":"10.1002\/jbm.a.37560","type":"journal-article","created":{"date-parts":[[2023,5,20]],"date-time":"2023-05-20T10:55:14Z","timestamp":1684580114000},"page":"1627-1641","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Biomimetic catheter surface with dual action <scp>NO<\/scp>\u2010releasing and generating properties for enhanced antimicrobial efficacy"],"prefix":"10.1002","volume":"111","author":[{"given":"Aasma","family":"Sapkota","sequence":"first","affiliation":[{"name":"School of Chemical, Materials &amp; Biomedical Engineering University of Georgia  Athens Georgia USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arnab","family":"Mondal","sequence":"additional","affiliation":[{"name":"School of Chemical, Materials &amp; Biomedical Engineering University of Georgia  Athens Georgia USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manjyot Kaur","family":"Chug","sequence":"additional","affiliation":[{"name":"School of Chemical, Materials &amp; Biomedical Engineering University of Georgia  Athens Georgia USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9283-5448","authenticated-orcid":false,"given":"Elizabeth J.","family":"Brisbois","sequence":"additional","affiliation":[{"name":"School of Chemical, Materials &amp; Biomedical Engineering University of Georgia  Athens Georgia USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,5,20]]},"reference":[{"key":"e_1_2_7_2_1","volume-title":"StatPearls. 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