{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,11]],"date-time":"2026-02-11T13:23:45Z","timestamp":1770816225230,"version":"3.50.1"},"reference-count":33,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2023,6,2]],"date-time":"2023-06-02T00:00:00Z","timestamp":1685664000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Biomedical Materials Res"],"published-print":{"date-parts":[[2023,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Segmental bone defects caused by trauma, tumor resection or congenital malformations are often reconstructed with autologous, allogeneic bone grafts or artificial bone materials, of which, about 5%\u2009~\u200910% will have delayed healing or even nonunion of fractures. The loss of periosteum and excessive accumulation of ROS in fracture site leads to the aging of osteoblasts and the decline of their proliferation and differentiation, thus affecting the fracture healing process. In this study, we prepared a functional modified artificial periosteum \u03b2\u2010TCP\/MnO<jats:sub>2<\/jats:sub>\/PCL(\u03b2\u2010TMP) by electrospinning with a function of catalyzing decomposition of H<jats:sub>2<\/jats:sub>O<jats:sub>2<\/jats:sub>. We examined the surface morphology of \u03b2\u2010TMP, the concentration of Ca, P and Mn of \u03b2\u2010TMP, as well as the diameter distribution range of nanofibers on \u03b2\u2010TMP. Through X\u2010ray diffraction patterns and Fourier transform infrared spectra, \u03b2\u2010TMP was characterized and its hydrophilicity was tested. The release of Mn<jats:sup>2+<\/jats:sup> and Ca<jats:sup>2+<\/jats:sup> of 0.1 and 0.05% \u03b2\u2010TMP in different pH values (7.4 and 5.5) determined by ICP. We also identified that \u03b2\u2010TMP could reduce the level of ROS in cells by lowering the level of H<jats:sub>2<\/jats:sub>O<jats:sub>2<\/jats:sub>. 0%, 0.05% and 0.1% \u03b2\u2010TMP displayed good cell compatibility, cell adhesion and cellular morphology in the condition with or without H<jats:sub>2<\/jats:sub>O<jats:sub>2<\/jats:sub>. 0.5% \u03b2\u2010TMP showed compromised cell compatibility in normal condition, however, the compromised phenotypes could be partially rescued in the present of H<jats:sub>2<\/jats:sub>O<jats:sub>2<\/jats:sub>. Compared with 0%, 0.05% and 0.1% \u03b2\u2010TMP displayed higher osteoblastic differentiation with or without H<jats:sub>2<\/jats:sub>O<jats:sub>2<\/jats:sub> in BMSCs as well as in MG\u201063. In sum, \u03b2\u2010TMP helped osteogenesis and promoted repair of bone defects.<\/jats:p>","DOI":"10.1002\/jbm.a.37576","type":"journal-article","created":{"date-parts":[[2023,6,2]],"date-time":"2023-06-02T14:58:44Z","timestamp":1685717924000},"page":"1678-1691","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Functional <scp>\u03b2\u2010TCP<\/scp>\/<scp>MnO<sub>2<\/sub><\/scp>\/<scp>PCL<\/scp> artificial periosteum promoting osteogenic differentiation of <scp>BMSCs<\/scp> by reducing locally reactive oxygen species level"],"prefix":"10.1002","volume":"111","author":[{"given":"Feng","family":"Qian","sequence":"first","affiliation":[{"name":"Department of Inorganic Materials School of Minerals Processing and Bioengineering, Central South University  Changsha China"},{"name":"Hunan Key Lab of Mineral Materials and Application Central South University  Changsha China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zongwang","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Inorganic Materials School of Minerals Processing and Bioengineering, Central South University  Changsha China"},{"name":"Hunan Key Lab of Mineral Materials and Application Central South University  Changsha China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wenbin","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Orthopedics The third Xiangya hospital, Central South University  Changsha China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1799-8044","authenticated-orcid":false,"given":"Yanling","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Urology, Provincial Laboratory for Diagnosis and Treatment of Genitourinary System Disease Xiangya Hospital, Central South University  Changsha 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China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2023,6,2]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13287-022-03125-2"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2016.10.055"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.4081\/or.2010.e23"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1155\/2014\/561459"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1177\/00220345211068338"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsnano.2c07200"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2022.121900"},{"issue":"1","key":"e_1_2_11_9_1","first-page":"79","article-title":"Nanostructured thick 3D nanofibrous scaffold can induce bone","volume":"25","author":"Eap S","year":"2015","journal-title":"Biomed Mater 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