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This has led to the adoption of autologous adipose engraftment procedures that allow for the injection of adipose tissues to be used as a \u201cfiller\u201d for correcting cosmetic defects and deformities in soft tissues. However, the clinical use of such methods has several limitations, including high resorption rates and poor cell survivability, which lead to low graft volume retention and inconsistent outcomes. Here, we describe a novel application of milled electrospun poly(lactic\u2010co\u2010glycolic acid) (PLGA) fibers, which can be co\u2010injected with adipose tissue to improve engraftment outcomes. These PLGA fibers had no significant negative impact on the viability of adipocytes in vitro and did not elicit long\u2010term proinflammatory responses in vivo. Furthermore, co\u2010delivery of human adipose tissue with pulverized electrospun PLGA fibers led to significant improvements in reperfusion, vascularity, and retention of graft volume compared to injections of adipose tissue alone. Taken together, the use of milled electrospun fibers to enhance autologous adipose engraftment techniques represents a novel approach for improving upon the shortcomings of such methods.<\/jats:p>","DOI":"10.1002\/jbm.a.37581","type":"journal-article","created":{"date-parts":[[2023,6,16]],"date-time":"2023-06-16T12:15:55Z","timestamp":1686917755000},"page":"1722-1733","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Injectable pulverized electrospun poly(lactic\u2010co\u2010glycolic acid) fibers improve human adipose tissue engraftment and volume retention"],"prefix":"10.1002","volume":"111","author":[{"given":"Devleena","family":"Das","sequence":"first","affiliation":[{"name":"Department of Biomedical Engineering The Ohio State University  Columbus Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8639-3420","authenticated-orcid":false,"given":"William 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