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Calcium deficient hydroxyapatite (also known as apatitic bone cement) is a potential bioactive bone substitute in orthopedics due to its chemical composition similar to that of natural bone minerals. In this study, fabrication of mannitol (a solid porogen) incorporated injectable synthetic (Syn) and eggshell derived (ESD) apatitic bone cements loaded with antibiotics (gentamicin\/meropenem\/ rifampicin\/vancomycin) was investigated. The release kinetics of the antibiotics were studied by fitting them with different kinetic models. All the antibiotics\u2010loaded apatitic bone cements set within clinically accepted setting time (20\u2009\u00b1\u20092\u2009min) and with good injectability (&gt;70%). The antibiotics released from these bone cements were found to be controlled and sustained throughout the study time. Weibull and Gompertz (applies in least initial burst and sustain drug release rate models) were the best models to predict the release behavior. They cements had acceptable compressive strength (6\u201310\u2009MPa; in the range of trabecular bone) and were biodegradable (21%\u201327% within 12\u2009weeks of incubation) in vitro in simulated body fluids at physiological conditions. These bone cements showed excellent antibacterial activity from day 1 onwards and no bacterial colony was found from day 3 onwards. The viability of MG63 cells in vitro after 72\u2009h was significantly higher after 24\u2009h (i.e., ~110%). The cells were well attached and spread over the surface of the cements with extended morphology. The ESD antibiotic\u2010loaded apatitic bone cements showed better injectability, degradation and cytocompatibility compared when compared to Syn antibiotic\u2010loaded apatitic bone cements. Thus, we believe that the ESD antibiotic\u2010loaded apatitic bone cements are suitable as potential injectable bone substitutes to avoid post\u2010operative implant associated and other acute or chronic bone infections.<\/jats:p>","DOI":"10.1002\/jbm.a.37584","type":"journal-article","created":{"date-parts":[[2023,6,25]],"date-time":"2023-06-25T01:18:39Z","timestamp":1687655919000},"page":"1750-1767","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Fabrication of injectable antibiotic\u2010loaded apatitic bone cements with prolonged drug delivery for treating post\u2010surgery infections"],"prefix":"10.1002","volume":"111","author":[{"given":"Vimal","family":"Kumar Dewangan","sequence":"first","affiliation":[{"name":"Department of Metallurgical and Materials Engineering Indian Institute of Technology Madras  Chennai India"},{"name":"Department of Biotechnology Indian Institute of Technology Madras  Chennai India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6268-3079","authenticated-orcid":false,"given":"T. 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