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In the present study, considering the advantages of PEEK in self\u2010initiated graft polymerization and of hydrogels in bone tissue engineering, we constructed a hydrogel coating (GPL) consisting of Gelatin methacryloyl (GelMA), methacrylamide\u2010modified \u03b5\u2010poly\u2010<jats:sc>l<\/jats:sc>\u2010lysine (\u03b5\u2010PLMA) and Laponite on PEEK through UV\u2010initiated crosslinking. The coating improved the hydrophilicity of PEEK, and the coating degraded slowly so that approximately 80% was retained after incubation in PBS for 8\u2009weeks. In vitro studies revealed that as compared to culturing on PEEK, culturing on PEEK\u2010GPL led to enhanced viability and adhesion of cultured human umbilical cord Wharton's jelly\u2010derived mesenchymal stem cells (hWJ\u2010MSCs). Due to the synergistic effect of the micron\u2010scale three\u2010dimensional surface and Laponite, PEEK\u2010GPL exhibited a significantly improved induction of osteogenic differentiation of hWJ\u2010MSCs compared to PEEK, as demonstrated by increased alkaline phosphatase activity, matrix mineralization, and expression of osteogenesis\u2010related genes. Furthermore, PEEK\u2010GPL showed antibacterial activity upon contact with <jats:italic>Staphylococcus aureus<\/jats:italic> and <jats:italic>Escherichia coli<\/jats:italic>, and this activity would be maintained before complete degradation of the hydrogel because the \u03b5\u2010PLMA was cross\u2010linked covalently into the coating. Thus, PEEK\u2010GPL achieved both osteogenesis and infection prevention in a single simple step, providing a feasible approach for the extensive use of PEEK in bone implants.<\/jats:p>","DOI":"10.1002\/jbm.a.37589","type":"journal-article","created":{"date-parts":[[2023,8,7]],"date-time":"2023-08-07T12:31:00Z","timestamp":1691411460000},"page":"1808-1821","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["Enhanced osteogenic and antibacterial properties of polyetheretherketone by ultraviolet\u2010initiated grafting polymerization of a gelatin methacryloyl\/epsilon\u2010poly\u2010L\u2010lysine\/laponite hydrogel coating"],"prefix":"10.1002","volume":"111","author":[{"given":"Yuhong","family":"Chen","sequence":"first","affiliation":[{"name":"Department of Prosthodontics, Affiliated Hospital of Stomatology Nanjing Medical University  Nanjing China"},{"name":"Jiangsu Key Laboratory of Oral Diseases  Nanjing 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