{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T14:24:00Z","timestamp":1791987840034,"version":"4.4.0"},"reference-count":59,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2023,9,8]],"date-time":"2023-09-08T00:00:00Z","timestamp":1694131200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81871459"],"award-info":[{"award-number":["81871459"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Biomedical Materials Res"],"published-print":{"date-parts":[[2024,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Magnesium alloys have been used to manufacture biodegradable implants, bone graft substitutes, and cardiovascular stents. WE43 was the most widely used magnesium alloy. The degradation process begins when the magnesium alloy stent is implanted in the body and comes into contact with body fluid. The degradation products include hydrogen, Mg<jats:sup>2+<\/jats:sup>, local alkaline environment, and unsoluble products. A large number of studies focused on Mg<jats:sup>2+<\/jats:sup> and pH in vitro, and in vivo of magnesium alloys, but few studies on unsoluble corrosion products (UCPs). In this study, UCPs of WE43 alloy were prepared by immersion in vitro, and their effects on macrophages were investigated. The results showed that the unsoluble corrosion products were Mg24Y5, Mg12YNd, and MgCO<jats:sub>3<\/jats:sub>\u00b73H<jats:sub>2<\/jats:sub>O, which were dose\u2010dependent on the apoptosis and necrosis of macrophages. After phagocytosis of UCPs, macrophages mainly metabolize in lysosome, and autophagy also participates in the metabolism of UCPs. It also decreases mitochondrial membrane potential and increases lysosomes, endoplasmic reticulum stress, and P2X7 receptor activation. These will increase reactive oxygen species (ROS) in cells, activating NLRP3 inflammatory corpuscles, activating the downstream pro\u2010IL18 and pro\u2010IL1\u03b2, and converting it to IL\u201018, and IL\u20101\u03b2. However, its pro\u2010inflammatory effect is far lower than that of the classical Lipopolysaccharide (LPS) pro\u2010inflammatory pathway. This work has increased our understanding of magnesium alloy metabolism and provides new ideas for the clinical application of magnesium alloys.<\/jats:p>","DOI":"10.1002\/jbm.a.37601","type":"journal-article","created":{"date-parts":[[2023,9,8]],"date-time":"2023-09-08T08:33:45Z","timestamp":1694162025000},"page":"6-19","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Effect of unsoluble corrosion products of <scp>WE43<\/scp> alloys in vitro on macrophages"],"prefix":"10.1002","volume":"112","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3879-8954","authenticated-orcid":false,"given":"Li","family":"Dong","sequence":"first","affiliation":[{"name":"Department of Cardiology The Fourth Affiliated Hospital of Harbin Medical University  Harbin China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhiyuan","family":"Shen","sequence":"additional","affiliation":[{"name":"Department of Cardiology The Fourth Affiliated Hospital of Harbin Medical University  Harbin China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huidi","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Cardiology The Fourth Affiliated Hospital of Harbin Medical University  Harbin China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Binmei","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Cardiology The Fourth Affiliated Hospital of Harbin Medical University  Harbin China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yinze","family":"Zhou","sequence":"additional","affiliation":[{"name":"Department of Cardiology The Fourth Affiliated Hospital of Harbin Medical University  Harbin China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xin","family":"Lv","sequence":"additional","affiliation":[{"name":"Department of Cardiology The First Affiliated Hospital of Harbin Medical University  Harbin China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaojian","family":"Hong","sequence":"additional","affiliation":[{"name":"Department of Cardiology The Fourth Affiliated Hospital of Harbin Medical University  Harbin China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiaren","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Clinical Lab The Fourth Affiliated Hospital of Harbin Medical University  Harbin China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Cardiology The Fourth Affiliated Hospital of Harbin Medical University  Harbin China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,9,8]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.carrev.2021.09.012"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40204-022-00182-x"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.msea.2009.11.061"},{"key":"e_1_2_9_5_1","article-title":"Magnesium\u2010based absorbable metal screws for intra\u2010articular fracture fixation","volume":"2016","author":"Biber R","year":"2016","journal-title":"Case Rep Orthop"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.actbio.2020.09.023"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijporl.2018.10.047"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10534-019-00170-y"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2006.11.042"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(07)60853-8"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1177\/0885328217743321"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.msec.2014.08.038"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.3109\/03008207.2014.923877"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.msec.2014.11.041"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1088\/1748-605X\/aaa9d5"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.msec.2015.08.043"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/jbm.b.34192"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.colsurfb.2020.111360"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1002\/jbm.a.35113"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1002\/jbm.b.31896"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.msec.2022.112693"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.actbio.2021.03.038"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.smim.2007.11.004"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.actbio.2022.08.015"},{"issue":"11","key":"e_1_2_9_25_1","first-page":"e922","article-title":"Preclinical investigation of neoatherosclerosis in magnesium\u2010based bioresorbable scaffolds versus thick\u2010strut drug\u2010eluting stents","volume":"16","author":"Nicol P","year":"2020","journal-title":"Euro Intervention"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1088\/1748-605X\/ac5574"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.1002\/advs.201902443"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.actbio.2021.01.031"},{"key":"e_1_2_9_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.actbio.2011.05.008"},{"key":"e_1_2_9_30_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsomega.9b02041"},{"key":"e_1_2_9_31_1","doi-asserted-by":"publisher","DOI":"10.1088\/1748-605X\/aca3e8"},{"key":"e_1_2_9_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.actbio.2010.12.004"},{"key":"e_1_2_9_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.msec.2017.02.126"},{"key":"e_1_2_9_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.actbio.2013.03.012"},{"key":"e_1_2_9_35_1","doi-asserted-by":"publisher","DOI":"10.1002\/jbm.a.31170"},{"key":"e_1_2_9_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.actbio.2015.11.030"},{"key":"e_1_2_9_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.msec.2020.111285"},{"key":"e_1_2_9_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.actbio.2020.02.002"},{"key":"e_1_2_9_39_1","doi-asserted-by":"publisher","DOI":"10.1088\/1748-6041\/5\/4\/045005"},{"key":"e_1_2_9_40_1","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v13.i29.4011"},{"key":"e_1_2_9_41_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.freeradbiomed.2009.12.022"},{"key":"e_1_2_9_42_1","doi-asserted-by":"publisher","DOI":"10.1088\/0957-4484\/27\/11\/112001"},{"key":"e_1_2_9_43_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.toxlet.2009.03.014"},{"key":"e_1_2_9_44_1","doi-asserted-by":"publisher","DOI":"10.1002\/jor.22411"},{"key":"e_1_2_9_45_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.esas.2009.11.005"},{"key":"e_1_2_9_46_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-4636(199804)40:1<104::AID-JBM12>3.0.CO;2-O"},{"key":"e_1_2_9_47_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.coi.2003.12.001"},{"key":"e_1_2_9_48_1","doi-asserted-by":"publisher","DOI":"10.1088\/1748-6041\/1\/1\/R01"},{"key":"e_1_2_9_49_1","doi-asserted-by":"publisher","DOI":"10.1111\/imr.12288"},{"key":"e_1_2_9_50_1","doi-asserted-by":"publisher","DOI":"10.1038\/nri2215"},{"key":"e_1_2_9_51_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bioactmat.2022.10.017"},{"key":"e_1_2_9_52_1","doi-asserted-by":"publisher","DOI":"10.1039\/C8TB01675E"},{"key":"e_1_2_9_53_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40204-014-0032-9"},{"key":"e_1_2_9_54_1","doi-asserted-by":"publisher","DOI":"10.1002\/jbm.b.33411"},{"issue":"14","key":"e_1_2_9_55_1","article-title":"Modulation of MAPK\u2010 and PI3\/AKT\u2010dependent autophagy signaling by stavudine (D4T) in PBMC of Alzheimer's disease patients","volume":"11","author":"La Rosa F","year":"2022","journal-title":"Cell"},{"key":"e_1_2_9_56_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.semcancer.2021.06.002"},{"key":"e_1_2_9_57_1","doi-asserted-by":"publisher","DOI":"10.1038\/nri2725"},{"key":"e_1_2_9_58_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-0039.2011.01780.x"},{"key":"e_1_2_9_59_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0891-5849(00)00317-8"},{"key":"e_1_2_9_60_1","doi-asserted-by":"publisher","DOI":"10.1002\/smll.201602410"}],"container-title":["Journal of Biomedical Materials Research Part A"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jbm.a.37601","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,12,30]],"date-time":"2023-12-30T21:11:52Z","timestamp":1703970712000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jbm.a.37601"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,9,8]]},"references-count":59,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2024,1]]}},"alternative-id":["10.1002\/jbm.a.37601"],"URL":"https:\/\/doi.org\/10.1002\/jbm.a.37601","archive":["Portico"],"relation":{},"ISSN":["1549-3296","1552-4965"],"issn-type":[{"value":"1549-3296","type":"print"},{"value":"1552-4965","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,9,8]]},"assertion":[{"value":"2023-02-17","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-08-16","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-09-08","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}