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Unfortunately, there is currently no effective clinical solution to promote endometrial regeneration after severe injury. In this study, we combined fibrinogen (Fg) and P(LLA\u2010CL) by electrostatic spinning to form a stable nano\u2010biomaterial Fg\/P(LLA\u2010CL), which can promote endometrial regeneration. After inducing physical injury to rat endometrium, we found that Fg\/P(LLA\u2010CL) membranes placed in the uterine cavities increased endometrial thickness and the number of glands after injury, while reducing the area of endometrial fibrosis. In addition, Fg\/P(LLA\u2010CL) increased neovascularization and decreased COL1A1 deposition. The expression of TGF\u2010\u03b21, a cytokine that promotes fibrosis, was down\u2010regulated in the early stage of injury. Finally, fertility assays confirmed that Fg\/P(LLA\u2010CL) improved the pregnancy rate in rats with endometrial injury, and its safety was verified by blood tests and pathological examination of heart, liver, spleen, lung, and kidney. Therefore, Fg\/P(LLA\u2010CL) shows great potential as a safe and nontoxic biomaterial for endometrial regeneration, ultimately improving pregnancy outcomes in patients with intrauterine adhesion.<\/jats:p>","DOI":"10.1002\/jbm.a.37604","type":"journal-article","created":{"date-parts":[[2023,9,19]],"date-time":"2023-09-19T09:05:28Z","timestamp":1695114328000},"page":"167-179","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Nano\u2010biomaterial Fibrinogen<scp>\/P<\/scp>(<scp>LLA\u2010CL<\/scp>) for prevention of intrauterine adhesion and restoration of fertility"],"prefix":"10.1002","volume":"112","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1628-0567","authenticated-orcid":false,"given":"Sirui","family":"Song","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynecology Tongji Hospital of Tongji University, Tongji University School of Medicine  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Siyu","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Tongji Hospital of Tongji University, Tongji University School of Medicine  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Danzeng","family":"Meiduo","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Tongji Hospital of Tongji University, Tongji University School of Medicine  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ping","family":"Chen","sequence":"additional","affiliation":[{"name":"School of Life Sciences and Technology Tongji University  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huaifang","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Tongji Hospital of Tongji University, Tongji University School of Medicine  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongbing","family":"He","sequence":"additional","affiliation":[{"name":"Shanghai Pine &amp; Power Biotech Co. 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