{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T16:14:47Z","timestamp":1791476087514,"version":"4.3.4"},"reference-count":49,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2023,11,9]],"date-time":"2023-11-09T00:00:00Z","timestamp":1699488000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82071954"],"award-info":[{"award-number":["82071954"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81102014"],"award-info":[{"award-number":["81102014"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Biomedical Materials Res"],"published-print":{"date-parts":[[2024,3]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Triple negative breast cancer (TNBC) has the worst prognosis of all breast cancers, and it is difficult to progress through traditional chemotherapy. Therefore, the treatment of TNBC urgently requires agents with effective diagnostic and therapeutic capabilities. In this study, we obtained programmed death\u2010ligand 1 (PD\u2010L1) antibody conjugated gold nanoshelled poly(lactic\u2010co\u2010glycolic acid) (PLGA) nanocapsules (NCs) encapsulating doxorubicin (DOX) (DOX@PLGA@Au\u2010PD\u2010L1 NCs). PLGA NCs encapsulating DOX were prepared by a modified single\u2010emulsion oil\u2010in\u2010water (O\/W) solvent evaporation method, and gold nanoshells were formed on the surface by gold seed growth method, which were coupled with PD\u2010L1 antibodies by carbodiimide method. The fabricated DOX@PLGA@Au\u2010PD\u2010L1 NCs exhibited promising contrast enhancement in vitro ultrasound imaging. Furthermore, DOX encapsulated in NCs displayed good pH\u2010responsive and photo\u2010triggered drug release properties. After irradiating 200\u2009\u03bcg\/mL NCs solution with a laser for 10\u2009min, the solution temperature increased by nearly 23\u00b0C, indicating that the NCs had good photothermal conversion ability. The targeting experiments confirmed that the NCs had specific target binding ability to TNBC cells overexpressing PD\u2010L1 molecules. Cell experiments exhibited that the agent significantly reduced the survival rate of TNBC cells through photochemotherapy combination therapy. As a multifunctional diagnostic agent, DOX@PLGA@Au\u2010PD\u2010L1 NCs could be used for ultrasound targeted contrast imaging and photochemotherapy combination therapy of TNBC cells, providing a promising idea for early diagnosis and treatment of TNBC.<\/jats:p>","DOI":"10.1002\/jbm.a.37638","type":"journal-article","created":{"date-parts":[[2023,11,9]],"date-time":"2023-11-09T04:37:56Z","timestamp":1699504676000},"page":"402-420","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Using\n                    <scp>anti\u2010PD\u2010L1<\/scp>\n                    antibody conjugated gold nanoshelled poly (\n                    <scp>Lactic\u2010co\u2010glycolic<\/scp>\n                    acid) nanocapsules loaded with doxorubicin: A theranostic agent for ultrasound imaging and photothermal\/chemo combination therapy of triple negative breast cancer"],"prefix":"10.1002","volume":"112","author":[{"given":"Hui","family":"Jiang","sequence":"first","affiliation":[{"name":"Department of Ultrasound, Renji Hospital Shanghai Jiao Tong University School of Medicine  Shanghai P. 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