{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,24]],"date-time":"2026-10-24T03:47:52Z","timestamp":1792813672706,"version":"4.5.0"},"reference-count":36,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2024,1,10]],"date-time":"2024-01-10T00:00:00Z","timestamp":1704844800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000069","name":"National Institute of Arthritis and Musculoskeletal and Skin Diseases","doi-asserted-by":"publisher","award":["R01 AR063701"],"award-info":[{"award-number":["R01 AR063701"]}],"id":[{"id":"10.13039\/100000069","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["I21 RX002901"],"award-info":[{"award-number":["I21 RX002901"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Biomedical Materials Res"],"published-print":{"date-parts":[[2024,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Tracheal stenosis is commonly caused by injury, resulting in inflammation and fibrosis. Inhibiting inflammation and promoting epithelization can reduce recurrence after initial successful treatment of tracheal stenosis. Steroids play an important role in tracheal stenosis management. This study in vitro evaluated effectiveness of a polydopaminated polycaprolactone stent coated with dexamethasone\u2010eluting poly(lactic\u2010co\u2010glycolic) acid microparticles (\u03bcPLGA) for tracheal stenosis management. Polydopamination was characterized by Raman spectroscopy and promoted epithelialization while dexamethasone delivery reduced macrophage activity, assessed by individual cell area measurements and immunofluorescent staining for inducible nitric oxide synthase (iNOS). Dexamethasone release was quantified by high\u2010performance liquid chromatography over 30\u2009days. Activation\u2010related increase in cell area and iNOS production by RAW 264.7 were both reduced significantly (<jats:italic>p<\/jats:italic>\u2009&lt;\u2009<jats:italic>.<\/jats:italic>05) through dexamethasone release. Epithelial cell spreading was higher on polydopaminated polycaprolactone (PCL) than PCL\u2010alone (<jats:italic>p<\/jats:italic>\u2009&lt;\u2009<jats:italic>.<\/jats:italic>05). Force required for stent migration was measured by pullout tests of PCL\u2010\u03bcPLGA stents from cadaveric rabbit and porcine tracheas (0.425\u2009\u00b1\u20090.068\u2009N and 1.082\u2009\u00b1\u20090.064\u2009N, respectively) were above forces estimated to occur during forced respiration. Biomechanical support provided by stents to prevent airway collapse was assessed by comparing compressive circumferential stiffness, and stiffness of the stent was about 1\/10th of the rabbit trachea (0.156\u2009\u00b1\u20090.023\u2009N\/mm vs. 1.420\u2009\u00b1\u20090.194\u2009N\/mm, respectively). A dexamethasone\u2010loaded PCL\u2010\u03bcPLGA stent platform can deliver dexamethasone and exhibits sufficient mechanical properties to anchor within the trachea and polydopamination of PCL is conducive to epithelial layer formation. Therefore, a polydopaminated PCL\u2010\u03bcPLGA stent is a promising candidate for in vivo evaluation for treatment of tracheal restenosis.<\/jats:p>","DOI":"10.1002\/jbm.a.37659","type":"journal-article","created":{"date-parts":[[2024,1,11]],"date-time":"2024-01-11T06:40:20Z","timestamp":1704955220000},"page":"781-792","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Dexamethasone eluting polydopaminated polycaprolactone\u2010poly (lactic\u2010co\u2010glycolic) acid for treatment of tracheal stenosis"],"prefix":"10.1002","volume":"112","author":[{"given":"Jacob","family":"Morand","sequence":"first","affiliation":[{"name":"Advanced Platform Center Louis Stokes Cleveland Veteran Affairs Medical Center  Cleveland Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Phillip","family":"McClellan","sequence":"additional","affiliation":[{"name":"Department of Urology Case Western Reserve University  Cleveland Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8100-0971","authenticated-orcid":false,"given":"Ilaha","family":"Isali","sequence":"additional","affiliation":[{"name":"Department of Urology Case Western Reserve University  Cleveland Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yusuf","family":"Dikici","sequence":"additional","affiliation":[{"name":"Department of Mechanical and Aerospace Engineering Case Western Reserve University  Cleveland Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Di","family":"Fan","sequence":"additional","affiliation":[{"name":"Department of Mechanical and Aerospace Engineering Case Western Reserve University  Cleveland Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Longshun","family":"Li","sequence":"additional","affiliation":[{"name":"Advanced Platform Center Louis Stokes Cleveland Veteran Affairs Medical Center  Cleveland Ohio USA"},{"name":"Department of Biomedical Engineering Case Western Reserve University  Cleveland Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew J.","family":"Shoffstall","sequence":"additional","affiliation":[{"name":"Advanced Platform Center Louis Stokes Cleveland Veteran Affairs Medical Center  Cleveland Ohio USA"},{"name":"Department of Biomedical Engineering Case Western Reserve University  Cleveland Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ozan","family":"Akkus","sequence":"additional","affiliation":[{"name":"Department of Mechanical and Aerospace Engineering Case Western Reserve University  Cleveland Ohio USA"},{"name":"Department of Biomedical Engineering Case Western Reserve University  Cleveland Ohio USA"},{"name":"Department of Orthopedic Surgery University Hospitals Cleveland Medical Center  Cleveland Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark","family":"Weidenbecher","sequence":"additional","affiliation":[{"name":"Advanced Platform Center Louis Stokes Cleveland Veteran Affairs Medical Center  Cleveland Ohio USA"},{"name":"Department of Otolaryngology Case Western Reserve University  Cleveland Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,1,10]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamaoto.2019.3022"},{"key":"e_1_2_9_3_1","article-title":"Metallic stents for proximal tracheal stenosis: is it worth the risk?","volume":"2012","author":"Bansal S","year":"2012","journal-title":"Case Rep Otolaryngol"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.athoracsur.2007.07.026"},{"issue":"3","key":"e_1_2_9_5_1","first-page":"258","article-title":"Indications and interventional options for non\u2010resectable tracheal stenosis","volume":"6","author":"Bacon JL","year":"2014","journal-title":"J Thorac Dis"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtcvs.2008.05.039"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2016.11.004"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsami.7b19865"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jchemed.8b00432"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2008.07.007"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1001\/archsurg.1986.01400100111021"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/0162-3109(95)00018-O"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1067\/mtc.2002.118503"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1001\/archotol.126.8.985"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/jbm.b.34277"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2005.09.019"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1378\/chest.12-2282"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.progpolymsci.2010.04.002"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtcvs.2010.08.008"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(03)12275-1"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.3390\/ma14102498"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1166\/jnn.2011.4495"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.3390\/pharmaceutics13091437"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.21873\/invivo.12819"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.colsurfb.2021.111949"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejps.2017.02.002"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.1002\/jbm.10016"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.1177\/0885328211412634"},{"key":"e_1_2_9_29_1","doi-asserted-by":"publisher","DOI":"10.3892\/mmr.2021.11953"},{"key":"e_1_2_9_30_1","doi-asserted-by":"publisher","DOI":"10.1002\/lary.30212"},{"key":"e_1_2_9_31_1","doi-asserted-by":"publisher","DOI":"10.1115\/1.2891228"},{"key":"e_1_2_9_32_1","doi-asserted-by":"publisher","DOI":"10.1039\/C8TB02310G"},{"key":"e_1_2_9_33_1","doi-asserted-by":"publisher","DOI":"10.1039\/C4TB00386A"},{"key":"e_1_2_9_34_1","doi-asserted-by":"publisher","DOI":"10.1002\/mabi.201500252"},{"key":"e_1_2_9_35_1","doi-asserted-by":"publisher","DOI":"10.1155\/2008\/358748"},{"key":"e_1_2_9_36_1","doi-asserted-by":"publisher","DOI":"10.3390\/sym10110595"},{"key":"e_1_2_9_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.icheatmasstransfer.2011.04.012"}],"container-title":["Journal of Biomedical Materials Research Part A"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jbm.a.37659","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,3,19]],"date-time":"2024-03-19T03:36:50Z","timestamp":1710819410000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jbm.a.37659"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,1,10]]},"references-count":36,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2024,5]]}},"alternative-id":["10.1002\/jbm.a.37659"],"URL":"https:\/\/doi.org\/10.1002\/jbm.a.37659","archive":["Portico"],"relation":{},"ISSN":["1549-3296","1552-4965"],"issn-type":[{"value":"1549-3296","type":"print"},{"value":"1552-4965","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,1,10]]},"assertion":[{"value":"2022-07-14","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-12-08","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-01-10","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}