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Electrospinning\u2010aid functionalization has the potential to improve the highly orchestrated response by attenuating the over\u2010activation of foreign body reactions. Herein, we combined poly(L\u2010lactic acid\u2010co\u2010caprolactone) (PLLA\u2010CL) with gelatin proportionally via electrospinning, with Ibuprofen (IBU) incorporation to fabricate a bilayer mesh for the repair improvement. The PLLA\u2010CL\/gelatin\/IBU (PGI) mesh was characterized in vitro and implanted into the rat model with a full\u2010thickness defect for a comprehensive evaluation in comparison to the PLLA\u2010CL\/gelatin (PG) and off\u2010the\u2010shelf small intestinal submucosa (SIS) meshes. The bilayer PGI mesh presented a sustained release of IBU over 21\u2009days with degradation in vitro and developed less\u2010intensive intraperitoneal adhesion along with a histologically weaker inflammatory response than the PG mesh after 28\u2009days. It elicited an M2 macrophage\u2010dominant foreign body reaction within the process, leading to a pro\u2010remodeling response similar to the biological SIS mesh, which was superior to the PG mesh. The PGI mesh provided preponderant mechanical supports over the SIS mesh and the native abdominal wall with similar compliance. Collectively, the newly developed mesh advances the intraperitoneal applicability of electrospun meshes by guiding a pro\u2010remodeling response and offers a feasible functionalization approach upon immunomodulation.<\/jats:p>","DOI":"10.1002\/jbm.a.37672","type":"journal-article","created":{"date-parts":[[2024,1,17]],"date-time":"2024-01-17T10:10:33Z","timestamp":1705486233000},"page":"941-955","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Ibuprofen\u2010loaded bilayer electrospun mesh modulates host response toward promoting full\u2010thickness abdominal wall defect repair"],"prefix":"10.1002","volume":"112","author":[{"given":"Jiajie","family":"Liu","sequence":"first","affiliation":[{"name":"Department of Hernia and Abdominal Wall Surgery, Shanghai East Hospital Tongji University  Shanghai People's Republic of 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