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A low\u2010cost method to induce bioactive healing has the potential to substantially improve patient care and prevent wound\u2010induced limb loss. A previous study reported that bioactive factors derived from apoptotic\u2010like mesenchymal stem cells (MSCs) demonstrated anti\u2010inflammatory and proangiogenic effects and improved ischemic muscle regeneration. In this work, these MSC\u2010derived bioactive factors were loaded into a hydrogel foam to harness immunomodulatory and angiogenic properties from MSC components to facilitate chronic wound healing without the high cost and translational challenges of cell therapies. After incorporation of bioactive factors, the hydrogel foam retained high absorbency, moisture retention, and target water vapor transmission rate. High loading efficiency was confirmed and release studies indicated that over 90% of loaded factors were released within 24\u2009h. Ethylene oxide sterilization and 4\u2010week storage did not affect the bioactive factor release profile or physical properties of the hydrogel foam dressing. Bioactivity retention of the released factors was also confirmed for as\u2010sterilized, 4\u00b0C\u2010stored, and \u221220\u00b0C\u2010stored bioactive hydrogel foams as determined by relevant gene expression levels in treated pro\u2010inflammatory (M1) macrophages. These results support the use of the bioactive dressings as an off\u2010the\u2010shelf product. Overall, this work reports a new method to achieve a first\u2010line wound dressing with the potential to reduce persistent inflammation and promote angiogenesis in chronic wounds.<\/jats:p>","DOI":"10.1002\/jbm.a.37678","type":"journal-article","created":{"date-parts":[[2024,1,25]],"date-time":"2024-01-25T12:26:45Z","timestamp":1706185605000},"page":"1388-1398","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Hydrogel foam dressings with angiogenic and immunomodulatory factors from mesenchymal stem cells"],"prefix":"10.1002","volume":"112","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7935-137X","authenticated-orcid":false,"given":"Ziyang","family":"Lan","sequence":"first","affiliation":[{"name":"Department of Biomedical Engineering the University of Texas at Austin  Austin Texas 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