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Inflammation and oxidative stress play an extremely important role in the development of AP disease. Polyvinylpyrrolidone\u2010modified iridium nanoparticles (IrNP\u2010PVP) have multienzyme mimetic activity, and the aim of this article is to discuss the therapeutic alleviative effects of the ultrasmall nanozymes IrNP\u2010PVP on AP through their antioxidant and anti\u2010inflammatory effects. IrNP\u2010PVP were proved to inhibit inflammation and scavenge reactive oxygen species (ROS) at the cellular level. The synthetic IrNP\u2010PVP exhibit remarkable antioxidant and anti\u2010inflammatory activities in the prevention and treatment of AP mice by establishing murine AP model, which can reduce the oxidative stress and inflammatory response. The results of this article indicated that the ultrasmall nanozymes IrNP\u2010PVP effectively alleviate AP via scavenging ROS as well as suppressing inflammation both in vivo and in vitro, which might provide enormous promise for the AP management.<\/jats:p>","DOI":"10.1002\/jbm.a.37679","type":"journal-article","created":{"date-parts":[[2024,2,7]],"date-time":"2024-02-07T02:29:26Z","timestamp":1707272966000},"page":"988-1003","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Ultrasmall polyvinylpyrrolidone\u2010modified iridium nanoparticles with antioxidant and anti\u2010inflammatory activity for acute pancreatitis alleviation"],"prefix":"10.1002","volume":"112","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3251-5792","authenticated-orcid":false,"given":"Wenzhang","family":"Jin","sequence":"first","affiliation":[{"name":"Department of Vascular Surgery The First Affiliated Hospital of Wenzhou Medical 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