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Patients with cystic fibrosis (CF) struggle with continuous bouts of pulmonary infections, contributing to lung destruction and eventual mortality. Additionally, CF patients struggle with airways that are highly viscous, with accumulated mucus creating optimal environments for bacteria colonization. The unique physiology and altered airway environment provide an ideal niche for bacteria to change their phenotype often becoming resistant to current treatments. Colonization with multiple pathogens at the same time further complicate treatment algorithms, requiring drug combinations that can challenge CF patient tolerance to treatment. The goal of this research initiative was to explore the utilization of a microparticle antibiotic delivery system, which could provide localized and sustained antibiotic dosing. The outcome of this work demonstrates the feasibility of providing efficient localized delivery of antibiotics to manage infection using both preclinical <jats:italic>in vitro<\/jats:italic> and <jats:italic>in vivo<\/jats:italic> CF infection models. The studies outlined in this manuscript demonstrate the proof\u2010of\u2010concept and unique capacity of polymerized cyclodextrin microparticles to provide site\u2010directed management of pulmonary infections.<\/jats:p>","DOI":"10.1002\/jbm.a.37680","type":"journal-article","created":{"date-parts":[[2024,2,21]],"date-time":"2024-02-21T12:35:32Z","timestamp":1708518932000},"page":"1305-1316","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Polymerized cyclodextrin microparticles for sustained antibiotic delivery in lung infections"],"prefix":"10.1002","volume":"112","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9698-9113","authenticated-orcid":false,"given":"Tracey L.","family":"Bonfield","sequence":"first","affiliation":[{"name":"Department of Genetics and Genome Sciences Case Western Reserve University  Cleveland Ohio USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sean 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