{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T19:42:02Z","timestamp":1790365322316,"version":"4.1.0"},"reference-count":35,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2024,3,11]],"date-time":"2024-03-11T00:00:00Z","timestamp":1710115200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Biomedical Materials Res"],"published-print":{"date-parts":[[2024,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The physicochemical properties of grafting materials affect the quality of the osteointegration, resorption rate, and the new bone (NB) formation. This study assessed the physicochemical properties and integration of a low temperature deproteinized bovine bone xenograft (BBX), referred to as optimized MoaBone\u00ae (OMB). This novel BBX was physiochemically characterized both pre and post chemical bleaching and sterilization by gamma irradiation. OMB was compared to two commercial BBX; Bio\u2010Oss\u00ae (BO) and MoaBone\u00ae (MB) using a rabbit cranial model. Residual graft and NB were quantified using histology and micro\u2010computed tomography. Results showed that chemical treatment and gamma irradiation had limited effect on the surface texture. A significant decrease in the collagen content was detected post chemical treatment and in the carbonate content post gamma irradiation. There was no evidence of inflammatory infiltrate, necrosis, or connective tissue encapsulation, and a significant increase of NB in all grafted sites as compared to untreated defects could be observed. However, there was no statistically significant difference between the grafted sites. We conclude that chemical treatment and terminal sterilization strongly impact the final graft's properties. OMB graft showed equivalence with BO for in vivo bone formation and potentially results in lower levels of graft retention.<\/jats:p>","DOI":"10.1002\/jbm.a.37693","type":"journal-article","created":{"date-parts":[[2024,3,11]],"date-time":"2024-03-11T13:06:15Z","timestamp":1710162375000},"page":"1436-1450","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["In vivo healing of low temperature deproteinized bovine bone xenograft in a rabbit cranial model"],"prefix":"10.1002","volume":"112","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6110-8064","authenticated-orcid":false,"given":"Dina","family":"Abdelmoneim","sequence":"first","affiliation":[{"name":"Sir John Walsh Research Institute, Faculty of Dentistry University of Otago  Dunedin New Zealand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dawn Elizabeth","family":"Coates","sequence":"additional","affiliation":[{"name":"Sir John Walsh Research Institute, Faculty of Dentistry University of Otago  Dunedin New Zealand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patrick","family":"Schmidlin","sequence":"additional","affiliation":[{"name":"Sir John Walsh Research Institute, Faculty of Dentistry University of Otago  Dunedin New Zealand"},{"name":"Clinic of Conservative and Preventive Dentistry, Center of Dental Medicine University of Zurich  Zurich Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sander","family":"Botter","sequence":"additional","affiliation":[{"name":"Swiss Center for Musculoskeletal Biobanking Balgrist Campus AG  Z\u00fcrich Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kai Chun","family":"Li","sequence":"additional","affiliation":[{"name":"Sir John Walsh Research Institute, Faculty of Dentistry University of Otago  Dunedin New Zealand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gemma Claire","family":"Porter","sequence":"additional","affiliation":[{"name":"Sir John Walsh Research Institute, Faculty of Dentistry University of Otago  Dunedin New Zealand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Benedict","family":"Seo","sequence":"additional","affiliation":[{"name":"Sir John Walsh Research Institute, Faculty of Dentistry University of Otago  Dunedin New Zealand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Warwick John","family":"Duncan","sequence":"additional","affiliation":[{"name":"Sir John Walsh Research Institute, Faculty of Dentistry University of Otago  Dunedin New Zealand"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,3,11]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.3390\/molecules26103007"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.matsci.28.1.271"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1708\u20108208.2011.00407.x"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/cid.12391"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.injury.2011.06.020"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.3390\/jfb9010018"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.4012\/dmj.2015\u2010255"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1155\/2012\/737262"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1136\/bjo.86.11.1287"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/s0142\u20109612(03)00621\u20105"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/jbm.10259"},{"key":"e_1_2_11_13_1","unstructured":"Heinz Lussi P. G.Process for preparing high purity bone mineral. ED GEISTLICH SOHNE AG fur CHEMICSHE INDUSTRIE 6110 WOLHUSEN LUCERNE SWITZERLAND Geistlich Sohne A G fur Chemische Industrie. (1988)."},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600\u20100501.2004.00986.x"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/clr.12170"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600\u20100501.1999.100605.x"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1708-8208.2001.tb00136.x"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.3390\/ma15082798"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.3390\/ma15072504"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.1177\/0885328218804926"},{"key":"e_1_2_11_21_1","unstructured":"FDA.Dental Bone Grafting Material Devices \u2010 Class II Special Controls Guidance for Industry and FDA Staff. Retrieved fromhttps:\/\/www.fda.gov\/medical\u2010devices\/guidance\u2010documents\u2010medical\u2010devices\u2010and\u2010radiation\u2010emitting\u2010products\/dental\u2010bone\u2010grafting\u2010material\u2010devices\u2010class\u2010ii\u2010special\u2010controls\u2010guidance\u2010industry\u2010and\u2010fda\u2010staff#f16"},{"key":"e_1_2_11_22_1","doi-asserted-by":"publisher","DOI":"10.1159\/000077054"},{"key":"e_1_2_11_23_1","doi-asserted-by":"publisher","DOI":"10.1038\/bdj.2007.893"},{"key":"e_1_2_11_24_1","doi-asserted-by":"publisher","DOI":"10.1111\/aor.12048"},{"key":"e_1_2_11_25_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10561\u2010006\u20109020\u20101"},{"key":"e_1_2_11_26_1","doi-asserted-by":"publisher","DOI":"10.1302\/0301\u2010620X.75B6.8245080"},{"key":"e_1_2_11_27_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1745\u20107270.2007.00320.x"},{"key":"e_1_2_11_28_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598\u2010018\u201019786\u20100"},{"key":"e_1_2_11_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/s0142\u20109612(01)00395\u20107"},{"key":"e_1_2_11_30_1","doi-asserted-by":"publisher","DOI":"10.2741\/e645"},{"key":"e_1_2_11_31_1","doi-asserted-by":"publisher","DOI":"10.1002\/1097\u20104636(200108)56:2<208::aid\u2010jbm1085>3.0.co;2\u2010r"},{"key":"e_1_2_11_32_1","doi-asserted-by":"publisher","DOI":"10.3109\/03008209509017003"},{"key":"e_1_2_11_33_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600\u20100501.2010.01939.x"},{"key":"e_1_2_11_34_1","doi-asserted-by":"publisher","DOI":"10.1002\/jbm.a.32373"},{"key":"e_1_2_11_35_1","doi-asserted-by":"publisher","DOI":"10.3390\/ma11101993"},{"key":"e_1_2_11_36_1","doi-asserted-by":"publisher","DOI":"10.11607\/jomi.4057"}],"container-title":["Journal of Biomedical Materials Research Part A"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jbm.a.37693","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,7,11]],"date-time":"2024-07-11T16:01:11Z","timestamp":1720713671000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jbm.a.37693"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,3,11]]},"references-count":35,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2024,9]]}},"alternative-id":["10.1002\/jbm.a.37693"],"URL":"https:\/\/doi.org\/10.1002\/jbm.a.37693","archive":["Portico"],"relation":{},"ISSN":["1549-3296","1552-4965"],"issn-type":[{"value":"1549-3296","type":"print"},{"value":"1552-4965","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,3,11]]},"assertion":[{"value":"2023-04-03","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-02-13","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-03-11","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}