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The microstructure, swelling ratio, area alteration and mechanical properties of RCS were characterized. Fifty\u2010four New Zealand rabbits performing incisor extraction on maxilla and mandible were randomly assigned into positive, sham operation or treatment groups. Micro\u2010computed tomography (micro\u2010CT) scans, performed after 1, 4, and 12\u2009weeks of surgery, were to assess changes in ridge height at buccal and palatal side, in ridge width and in micromorphological parameters. Histological analysis accessed socket microarchitecture. The results showed that RCS had stable mechanical properties and morphologic features that provided a reliable physical support for ARP. Dimensional changes in treatment group revealed significantly greater vertical height at buccal (5.32 [3.37, 7.26]\u2009mm, <jats:italic>p<\/jats:italic>\u2009&lt;\u2009.0001) and palatal (4.37 [2.66, 6.09]\u2009mm, <jats:italic>p<\/jats:italic>\u2009&lt;\u2009.0001) side, and horizontal width at the maxilla (0.16 [0.04, 0.28]\u2009mm, <jats:italic>p<\/jats:italic>\u2009&lt;\u2009.01) and mandible (0.33 [0.11, 0.54]\u2009mm, <jats:italic>p<\/jats:italic>\u2009&lt;\u2009.01) than those in sham operation group after 12\u2009weeks. The treatment group had advantage than positive group in vertical height preservation, quantitatively. The order and density of bone trabeculae were improved in treatment group. These findings indicated that RCS had the potential to serve as an effective scaffold for ARP.<\/jats:p>","DOI":"10.1002\/jbm.a.37723","type":"journal-article","created":{"date-parts":[[2024,4,12]],"date-time":"2024-04-12T10:39:28Z","timestamp":1712918368000},"page":"1699-1711","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Effect of radiation cross\u2010linked collagen scaffold in alveolar ridge preservation of extraction socket"],"prefix":"10.1002","volume":"112","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7995-7192","authenticated-orcid":false,"given":"Hongwei","family":"Li","sequence":"first","affiliation":[{"name":"State Key Laboratory of Vaccines for Infectious Diseases, Xiang An Biomedicine Laboratory, State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics, National Innovation Platform for Industry\u2010Education Integration in Vaccine Research, School of Public Health Xiamen 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