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This study introduces a method employing biomimetic hydroxyapatite (Hap) deposition guided by molecularly organized phospholipids, affixed to the metal implant surface. Using the Langmuir\u2013Blodgett technique, phospholipids were deposited onto Ti\u2010screws by using CaCl\n                    <jats:sub>2<\/jats:sub>\n                    or CaCl\n                    <jats:sub>2<\/jats:sub>\n                    \/SrCl\n                    <jats:sub>2<\/jats:sub>\n                    aqueous solution in the subphase of a Langmuir trough in the target proportion (i.e. 10 and 90\u2009mol% of Sr\n                    <jats:sup>2+<\/jats:sup>\n                    in relation of Ca\n                    <jats:sup>2+<\/jats:sup>\n                    ) followed by immersion in phosphate buffer and in supersaturated simulated body fluid. Coating composition and morphology were evaluated using infrared spectroscopy and scanning electron microscopy, respectively, while contact angle measurements assessed coating wettability and surface energy. Randomized screws were then implanted into the tibias of healthy and osteoporotic female rats (G1: Control\u2010Machined, G2: Hap, G3: HapSr10, G4: HapSr90). Osseointegration, assessed 60\u2009days post\u2010implantation, included reverse torque, fluorochrome area, bone tissue\u2010screw contact area, and linear extent of bone\u2010screw contact. Results, grouped by surface treatment (Machined, Hap, HapSr10, HapSr90), revealed that the deposition of Hap, HapSr10, and HapSr90 resulted in thin and rough coatings composed of hydroxyapatite (Hap) on the screw surface with nanoscale pores. The coatings resulted in increased wettability and surface energy of Ti surfaces. The minerals are chemically similar to natural bone apatite as revealed by FTIR analysis. In vivo analyses indicated higher torque values for strontium\u2010containing surfaces in the osteoporotic group (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.02) and, in the control group superior torque for screw removal on the Hap surface (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.023). Hydroxyapatite\u2010treated surfaces enhance morphology, composition, and reactivity, promoting screw osseointegration in healthy and osteoporotic female rats. The incorporation of strontium into the mineral phase has been proposed to not only stimulate osteoblast activity but also reduce osteoclastic resorption, which may explain the improved outcomes observed here in experimental osteoporotic conditions.\n                  <\/jats:p>","DOI":"10.1002\/jbm.a.37782","type":"journal-article","created":{"date-parts":[[2024,10,3]],"date-time":"2024-10-03T08:23:44Z","timestamp":1727943824000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Strontium\u2010containing mineralized phospholipid coatings improve osseointegration in osteoporotic rats"],"prefix":"10.1002","volume":"113","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2433-8167","authenticated-orcid":false,"given":"Hiskell Francine","family":"Fernandes e Oliveira","sequence":"first","affiliation":[{"name":"Department of Dental Materials and Prosthodontics, School of Dentistry S\u00e3o Paulo State University (Unesp)  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Faculty of Philosophy, Sciences and Letters of Ribeir\u00e3o Preto University of S\u00e3o Paulo  S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3772-8444","authenticated-orcid":false,"given":"Lucas Fabricio Bahia","family":"Nogueira","sequence":"additional","affiliation":[{"name":"Department of Chemistry, Faculty of Philosophy, Sciences and Letters of Ribeir\u00e3o Preto University of S\u00e3o Paulo  S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6773-6966","authenticated-orcid":false,"given":"Roberta","family":"Okamoto","sequence":"additional","affiliation":[{"name":"Department of Diagnosis and Surgery, School of Dentistry S\u00e3o Paulo State University (Unesp)  Ara\u00e7atuba Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6464-5305","authenticated-orcid":false,"given":"Ana Carla 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