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This is important in the treatment of wounds with irregular shapes and depth. This study identified an injectable hydrogel formulation of porcine cholecyst extracellular matrix (60%) in medical\u2010grade carboxymethyl cellulose (40%) as vehicle and evaluated its biomaterial properties. Further, an in\u2010depth evaluation of\n                    <jats:italic>in vivo<\/jats:italic>\n                    wound healing efficacy was conducted in a rat full\u2010thickness skin excision wound healing model, which revealed that the hydrogel formulation accelerated wound healing process compared to wounds treated with a commercial formulation and untreated wounds. The hydrogel appeared to have promoted a desirable pro\u2010regenerative tissue reaction predominated by Th2 helper lymphocytes and M2 macrophages as well as an effective collagen remodeling indicative of diminished scarring. In conclusion, the porcine cholecyst extracellular matrix injectable hydrogel formulation appeared to be a promising candidate formulation as an advanced wound care biomaterial for faster healing of skin wounds with minimal scarring.\n                  <\/jats:p>","DOI":"10.1002\/jbm.a.37795","type":"journal-article","created":{"date-parts":[[2024,10,9]],"date-time":"2024-10-09T05:35:38Z","timestamp":1728452138000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["An injectable hydrogel of porcine cholecyst extracellular matrix for accelerated wound healing"],"prefix":"10.1002","volume":"113","author":[{"given":"Kanakarajan V.","family":"Pratheesh","sequence":"first","affiliation":[{"name":"Division of Experimental Pathology Biomedical Technology Wing, Sree Chitra Tirunal Institute for Medical Sciences and Technology  Thiruvananthapuram India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Reshma 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