{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T01:44:59Z","timestamp":1791942299702,"version":"4.3.4"},"reference-count":78,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2024,10,30]],"date-time":"2024-10-30T00:00:00Z","timestamp":1730246400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2024,10,30]],"date-time":"2024-10-30T00:00:00Z","timestamp":1730246400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Biomedical Materials Res"],"published-print":{"date-parts":[[2025,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>The majority of issues related to patients suffering from conductive hearing loss and repeated otitis media are due to chronic tympanic membrane perforations. This generally requires a surgical procedure called tympanoplasty to seal the perforation where autologous grafts are used to reconstruct the membrane. However, the limitations associated with surgical procedures and the limited graft\u2010material availability often cause difficulties in this route; demanding novel procedures or materials. The basic requirements for a synthetic graft\u2010material for this application cover excellent cell adherence with no immune response and inflammatory actions at the site of implantation along with wound\u2010healing characteristics and sufficient acoustic and mechanical properties. With this aim, an innovative graft material has been developed with polyvinyl alcohol (PVA) as the base component through this work. To ensure better cell adhesion and proliferation, a natural polymer, gelatin, has been cross\u2010linked with PVA through a maleic anhydride (MA) intermediate; with a two\u2010step synthesis protocol. The mechanical strength of graft material has been found to be tunable by adjusting the ratio of gelatin with PVA. Laser Doppler Vibrometry (LDV) has been employed to evaluate its acoustic properties upon exposure to a frequency sweep of 10\u20148000\u2009Hz. The in\u00a0vitro biocompatibility assays using L929 and RPMI 2650 cells substantiate the material's compatibility; ensuring its potential clinical applications toward chronic tympanic membrane perforations.<\/jats:p>","DOI":"10.1002\/jbm.a.37818","type":"journal-article","created":{"date-parts":[[2024,10,30]],"date-time":"2024-10-30T09:51:44Z","timestamp":1730281904000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Functionalized Polyvinyl Alcohol\u2013Gelatin Graft for the Treatment of Tympanic Membrane Perforations"],"prefix":"10.1002","volume":"113","author":[{"given":"Jasmin","family":"Joseph","sequence":"first","affiliation":[{"name":"Department of Chemistry National Institute of Technology Calicut  Kozhikode India"},{"name":"Division of Polymeric Medical Devices Sree Chitra Tirunal Institute for Medical Sciences and Technology  Thiruvananthapuram 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