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This study proposed a biocomposite film composed of natural polymer chitosan (CS) and synthetic polymer poly\u2010\u0190\u2010caprolactone (PCL) reinforced with sol\u2013gel\u2010derived bioactive glass (BG) for potential application in TE. The BG\/PCL\/CS biocomposite film was sterilized using 25\u2009kGy gamma rays, and subsequent changes in its characteristics were analyzed through mechanical and physical assessment, bioactivity evaluation via immersion in simulated body fluid (SBF) and biocompatibility examination using human primary dermal fibroblasts (HPDFs). Results indicated a homogeneous distribution of BG particles within the BG\/PCL\/CS polymer matrix which enhanced bioactivity, and the polymer blend provide a structurally stable film. Gamma irradiation induced an increase in the film's surface roughness due to photo\u2010oxidative degradation; however, this did not adversely affect the integrity of glass particles and polymer chains. In\u00a0vitro assessments demonstrated hydroxyapatite formation on the film's surface, suggesting bioactivity. Biocompatibility testing confirmed enhanced cell adhesion and proliferation. These multifunctional properties highlight the potential of the fabricated BG\/PCL\/CS biocomposite film for TE and regenerative medicine applications.<\/jats:p>","DOI":"10.1002\/jbm.a.37842","type":"journal-article","created":{"date-parts":[[2024,12,13]],"date-time":"2024-12-13T04:27:14Z","timestamp":1734064034000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Effects of Gamma Irradiation on Structural, Chemical, Bioactivity and Biocompatibility Characteristics of Bioactive Glass\u2013Polymer Composite Film"],"prefix":"10.1002","volume":"113","author":[{"given":"Mamun Khan","family":"Sujon","sequence":"first","affiliation":[{"name":"Department of Dental Science, Advanced Medical and Dental Institute Universiti Sains Malaysia  Kepala Batas Pulau Pinang Malaysia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Siti Fatimah","family":"Samsurrijal","sequence":"additional","affiliation":[{"name":"Department of Dental Science, Advanced Medical and Dental Institute Universiti Sains Malaysia  Kepala Batas Pulau Pinang Malaysia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruzalina","family":"Baharin","sequence":"additional","affiliation":[{"name":"Technical Support Division Malaysian Nuclear Agency  Kajang Selangor Malaysia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naurah Mat","family":"Isa","sequence":"additional","affiliation":[{"name":"Radiation Processing Technology Division Malaysian Nuclear Agency  Kajang Selangor Malaysia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0313-0156","authenticated-orcid":false,"given":"Muhammad Azrul","family":"Zabidi","sequence":"additional","affiliation":[{"name":"Department of Dental Science, Advanced Medical and Dental Institute Universiti Sains Malaysia  Kepala Batas Pulau Pinang Malaysia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9200-265X","authenticated-orcid":false,"given":"Siti Noor Fazliah","family":"Mohd Noor","sequence":"additional","affiliation":[{"name":"Department of Dental Science, Advanced Medical and Dental Institute Universiti Sains Malaysia  Kepala Batas Pulau Pinang Malaysia"},{"name":"Dental Stimulation and Virtual Learning, Research Excellence Consortium, Advanced Medical and Dental Institute Universiti Sains Malaysia  Kepala Batas Pulau Pinang Malaysia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,12,13]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1369\u20107021(11)70058\u2010X"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10856\u2010019\u20106245\u20107"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0141\u20103910(02)00362\u20102"},{"key":"e_1_2_9_5_1","unstructured":"Food and Drug Administration. 2008.Submission and Review of Sterility Information in Premarket Notification: Submissions for Devices Labeled as Sterile. 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