{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T01:44:49Z","timestamp":1791942289267,"version":"4.3.4"},"reference-count":62,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2024,12,24]],"date-time":"2024-12-24T00:00:00Z","timestamp":1734998400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2024,12,24]],"date-time":"2024-12-24T00:00:00Z","timestamp":1734998400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Biomedical Materials Res"],"published-print":{"date-parts":[[2025,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Osteoarthritis (OA) is a significant condition that profoundly impacts synovial joints, including cartilage and subchondral bone plate. Biomaterials that can impede OA progression are a promising alternative or supplement to anti\u2010inflammatory and surgical interventions. Magnesium (Mg) alloys known for bone regeneration potential were assessed in the form of Mg microparticles regarding their impact on tissue regeneration and prevention of OA progression. In\u00a0vitro assays based on mesenchymal stem cells (SCP\u20101) were applied to evaluate the Mg microparticle's compatibility and function. Biocompatibility documented through live\u2010dead staining and lactate dehydrogenase assay revealed a 90% cell viability at a concentration below 10\u2009mM after 3\u2009days of exposure. An in\u00a0vitro OA model based on the supplementation of the cytokines IL\u20101\u03b2, and TNF\u2010\u03b1 was established and disclosed the effect of Mg degradation products in differentiating SCP\u20101 cells. Sustained differentiation was confirmed through extracellular matrix staining and increased gene marker expression. The Mg supplementation reduced the release of inflammatory cytokines (IL\u20106 and IL\u20108) while promoting the expression of proteins such as collagen X, collagen I, and osteopontin in a time\u2010dependent manner. The in\u00a0vitro study suggests that Mg microparticles hold a therapeutic potential for OA treatment with their ability to support bone and cartilage repair mechanisms even under inflammatory conditions.<\/jats:p>","DOI":"10.1002\/jbm.a.37862","type":"journal-article","created":{"date-parts":[[2024,12,25]],"date-time":"2024-12-25T02:50:46Z","timestamp":1735095046000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Investigating the Potential of Magnesium Microparticles on Cartilage and Bone Regeneration Utilizing an In\u00a0Vitro Osteoarthritis Model"],"prefix":"10.1002","volume":"113","author":[{"given":"Bavya Mavila","family":"Chathoth","sequence":"first","affiliation":[{"name":"Helmholtz Zentrum Hereon Institute of Metallic Biomaterials  Geesthacht Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Heike","family":"Helmholz","sequence":"additional","affiliation":[{"name":"Helmholtz Zentrum 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