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Flexible conductive materials with mechanical properties similar to those of biological tissues have been shown to have better long\u2010term biointegration and functionality than rigid conductive materials. In this study, liquid metal (LM)\u2010based conductive polycaprolactone\/gelatin\/polypyrrole\/LM (PCL\/Gel\/PPy\/LM, PGPL) NGC was combined with exogenous ES to repair PNI. PGPL membranes had good hydrophilicity, degradability, and mechanical properties, and its conductivity reached 0.66\u2009\u00b1\u20090.02\u2009S\/m. In\u00a0vitro studies showed that the combination of PGPL membranes and ES (2\u2009Hz, 100\u2009mV\/cm, 30\u2009min\/d) could significantly increase the expression of neuromarkers and had a better pro\u2010neural differentiation effect. In\u00a0vivo studies demonstrated that PGPL NGCs in combination with ES (2\u2009Hz, 200\u2009mV\/mm, 30\u2009min\/d) could effectively promote morphological reconstruction and functional recovery of the sciatic nerve in rats. At 3\u2009months post\u2010surgery, PGPL NGCs combined with ES restored the nerve conduction velocity to 73.85%\u2009\u00b1\u20095.45% of the normal value. The LM\u2010based NGCs prepared in this study could effectively repair long sciatic nerve defects, which may further expand the application of LM in the field of nerve tissue engineering.<\/jats:p>","DOI":"10.1002\/jbm.a.37880","type":"journal-article","created":{"date-parts":[[2025,2,2]],"date-time":"2025-02-02T09:49:56Z","timestamp":1738489796000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Liquid Metal\u2010Based Conductive Nerve Guidance Conduit Combined With Electrical Stimulation Boosts Peripheral Nerve Repair"],"prefix":"10.1002","volume":"113","author":[{"given":"Yujie","family":"Zhu","sequence":"first","affiliation":[{"name":"State Key Laboratory of New Textile Materials and Advanced Processing Technologies Wuhan Textile University  Wuhan P. R. 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