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Despite the widespread adoption in tissue engineering, the rapid degradation of small intestinal submucosa (SIS) compromised its performance in gastric tissue engineering. Thereby, genipin, a natural crosslinking agent, was employed to modify SIS, and the potential of genipin\u2010crosslinked SIS (GP\u2010SIS) in promoting the regeneration of full\u2010thickness gastric defects was explored. The data on crosslinking efficiency demonstrated that genipin can efficiently fix SIS. GP\u2010SIS exhibited high resistance against collagenase, enhanced hydrothermal stability, and improved mechanical properties according to in\u00a0vitro degradation, shrinkage temperature, and uniaxial tensile tests. Additionally, GP\u2010SIS maintained excellent biocompatibility based on a cytotoxicity test and rat subcutaneous implantation. In the rat full\u2010thickness gastric wall defect model, GP\u2010SIS, serving as a protective barrier, accelerated the newly formed granulation tissues and fibrosis, avoiding the occurrence of gastric leakage. Its niche and growth factors further promoted the vascularization and epithelialization of the regenerated area. In conclusion, GP\u2010SIS will be feasible in the near future for gastric wall reconstruction after gastrectomy.<\/jats:p>","DOI":"10.1002\/jbm.a.37899","type":"journal-article","created":{"date-parts":[[2025,3,29]],"date-time":"2025-03-29T00:15:41Z","timestamp":1743207341000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Evaluation of Genipin\u2010Crosslinked Small Intestinal Submucosa for a Full\u2010Thickness Gastric Defect Repair"],"prefix":"10.1002","volume":"113","author":[{"given":"Yuzhuo","family":"Wang","sequence":"first","affiliation":[{"name":"School of Life Science and Technology Shandong Second Medical University  Weifang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chao","family":"Yin","sequence":"additional","affiliation":[{"name":"Medical Department Hanting District Gaoli Town Central Hospital  Weifang 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