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Vascularizing microgels may aid in efforts to develop complex, multiphasic tissues by providing discrete, vascularized tissue modules that can be distributed throughout engineered constructs to vascularize large volumes. Here, we fabricated poly(ethylene glycol)\u2010norbornene (PEGNB) microgels containing endothelial and stromal cells via flow\u2010focusing microfluidic droplet generation. When embedded in bulk fibrin hydrogels, these cell\u2010laden microgels initiated the formation and development of robust microvascular networks. Furthermore, extended preculture of cell\u2010laden PEGNB microgels enabled the formation of vessel\u2010like structures supported by basement membrane within the matrix without aggregation. Our findings highlight the suitability of PEG\u2010based matrices for the development of vascularizing microgels capable of forming well\u2010distributed, robust microvascular networks.<\/jats:p>","DOI":"10.1002\/jbm.a.37900","type":"journal-article","created":{"date-parts":[[2025,3,29]],"date-time":"2025-03-29T00:22:29Z","timestamp":1743207749000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Biofabrication and Characterization of Vascularizing\n                    <scp>PEG<\/scp>\n                    \u2010Norbornene Microgels"],"prefix":"10.1002","volume":"113","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5090-6538","authenticated-orcid":false,"given":"Nicole E.","family":"Friend","sequence":"first","affiliation":[{"name":"Department of Biomedical Engineering University of Michigan  Ann Arbor Michigan 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