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The mats exhibited a unique morphology, combining fibers and beads, with average fiber diameters of 570\u2009nm for 12% (w\/v) PCL and 470\u2009nm for 1% (w\/v) PEG in 12% (w\/v) PCL, and bead diameters of 11.34\u2009\u03bcm and 10.43\u2009\u03bcm, respectively. PEG incorporation rendered the mats hydrophilic and significantly enhanced their swelling capacity, which is essential for wound exudate management. Remarkably, iodine was incorporated at a concentration specifically optimized to achieve its minimum inhibitory concentration (MIC) against a range of microorganisms while preserving the structural integrity and release profile of the mats. While PEG facilitated a higher initial iodine release rate, equilibrium was achieved after 5\u2009days. UV\u2013Vis spectroscopy unveiled the formation of transient iodine complexes with both PCL and PEG, underscoring their functional synergy. Biological assays revealed that PCL\/PEG mats loaded with 4.26\u2009mg\/mL of iodine (PCL\/PEG 3MIC) exhibited potent antimicrobial efficacy against gram\u2010positive and gram\u2010negative bacteria, as well as fungi, alongside significant in\u00a0vitro wound healing potential. These findings underscore the promise of PCL\/PEG iodine\u2010loaded mats as an innovative platform for next\u2010generation antimicrobial wound care, combining effective infection control with enhanced wound healing capabilities.<\/jats:p>","DOI":"10.1002\/jbm.a.37913","type":"journal-article","created":{"date-parts":[[2025,4,9]],"date-time":"2025-04-09T03:24:42Z","timestamp":1744169082000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Sub\u2010Micrometer Polycaprolactone and Polyethylene Glycol\u2010Based Fiber Mats With Iodine and Its Potential for Wound Healing"],"prefix":"10.1002","volume":"113","author":[{"given":"Agnes Chacor","family":"de Figueiredo","sequence":"first","affiliation":[{"name":"COPPE\/Program of Metallurgical and Materials Engineering \u2013 PEMM Universidade Federal do Rio de Janeiro (UFRJ)  Rio de Janeiro Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bruna Nunes","family":"Teixeira","sequence":"additional","affiliation":[{"name":"COPPE\/Program of Metallurgical and Materials Engineering \u2013 PEMM Universidade Federal do Rio de Janeiro (UFRJ)  Rio de Janeiro Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Javier Mauricio","family":"Anaya\u2010Mancipe","sequence":"additional","affiliation":[{"name":"COPPE\/Program of Metallurgical and Materials Engineering \u2013 PEMM Universidade Federal do Rio de Janeiro (UFRJ)  Rio de Janeiro Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ver\u00f4nica Silva","family":"Cardoso","sequence":"additional","affiliation":[{"name":"Institute of Microbiology Paulo de G\u00f3es (IMPG) Universidade Federal do Rio de Janeiro  Rio de Janeiro Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alane Beatriz","family":"Vermelho","sequence":"additional","affiliation":[{"name":"Institute of Microbiology Paulo de G\u00f3es (IMPG) Universidade Federal do Rio de Janeiro  Rio de Janeiro Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0026-5431","authenticated-orcid":false,"given":"Rossana Mara","family":"da Silva Moreira Thir\u00e9","sequence":"additional","affiliation":[{"name":"COPPE\/Program of Metallurgical and Materials Engineering \u2013 PEMM Universidade Federal do Rio de Janeiro (UFRJ)  Rio de Janeiro Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,4,9]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.12968\/jowc.2019.28.Sup3a.S1"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.12968\/bjon.2020.29.5.S6"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1089\/wound.2016.0697"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1089\/wound.2014.0586"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.7603\/s40681\u2010015\u20100022\u20109"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijsu.2017.06.073"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajps.2022.01.001"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.biomac.0c00760"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/app.52178"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/iwj.12578"},{"issue":"3","key":"e_1_2_9_12_1","first-page":"232","article-title":"Povidone\u2010Iodine in Wound Healing and Prevention of Wound Infections","volume":"10","author":"Gmur M. 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