{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,23]],"date-time":"2026-07-23T17:11:39Z","timestamp":1784826699093,"version":"3.55.0"},"reference-count":37,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2025,4,22]],"date-time":"2025-04-22T00:00:00Z","timestamp":1745280000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100002923","name":"Consejo Nacional de Investigaciones Cient\u00edficas y T\u00e9cnicas","doi-asserted-by":"publisher","award":["PIP\u2010118\/21,PIP\u2010349\/23"],"award-info":[{"award-number":["PIP\u2010118\/21,PIP\u2010349\/23"]}],"id":[{"id":"10.13039\/501100002923","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Biomedical Materials Res"],"published-print":{"date-parts":[[2025,5]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:p>Drawing inspiration from the extracellular matrix (ECM), where fiber organization profoundly influences cell behavior, electrospun scaffolds have emerged as powerful tools for modulating cellular responses in\u00a0vitro. While electrospinning enables the replication of ECM architecture, selecting suitable materials is paramount for effective cell adhesion and growth. In this study, we aimed to develop cost\u2010effective scaffolds for human adipose\u2010derived mesenchymal stromal cells (hAD\u2010MSCs) using gelatin methacrylate (GelMA) blended with either polycaprolactone (PCL) or poly(ethylene glycol) dimethacrylate (PEGDMA). Through comparing randomly oriented and aligned fibers, we identified fiber direction as a critical factor in determining cell behavior. Surprisingly, we found that despite material hydrophobicity, the cells aligned with the fiber direction, highlighting the dominant influence of fiber alignment on cell spreading. This research underscores the importance of material selection and fiber orientation in engineering scaffolds for directing cell behavior in tissue regeneration applications.<\/jats:p>","DOI":"10.1002\/jbm.a.37914","type":"journal-article","created":{"date-parts":[[2025,4,22]],"date-time":"2025-04-22T10:25:37Z","timestamp":1745317537000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Nanofibrous <scp>GelMA<\/scp>\u2010Based Scaffolds Support Human Adipose\u2010Derived Mesenchymal Stem\/Stromal Cell Adhesion, Viability, and Growth"],"prefix":"10.1002","volume":"113","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1428-5890","authenticated-orcid":false,"given":"Lautaro","family":"Rivera","sequence":"first","affiliation":[{"name":"Instituto de Histolog\u00eda y Embriolog\u00eda de Mendoza (IHEM, CONICET\u2010Universidad Nacional de Cuyo)  Mendoza Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6922-7751","authenticated-orcid":false,"given":"Matth\u00e4us Davi","family":"Popov Pereira da Cunha","sequence":"additional","affiliation":[{"name":"Instituto de Investigaciones en Ciencia y Tecnolog\u00eda de Materiales (INTEMA, CONICET\u2010Universidad Nacional de Mar del Plata)  Mar del Plata Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-0200-9785","authenticated-orcid":false,"given":"Roc\u00edo Jazm\u00edn","family":"Sabbatella","sequence":"additional","affiliation":[{"name":"Instituto de Investigaciones en Ciencia y Tecnolog\u00eda de Materiales (INTEMA, CONICET\u2010Universidad Nacional de Mar del Plata)  Mar del Plata Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5411-6154","authenticated-orcid":false,"given":"Samanta","family":"del Veliz","sequence":"additional","affiliation":[{"name":"Instituto de Histolog\u00eda y Embriolog\u00eda de Mendoza (IHEM, CONICET\u2010Universidad Nacional de Cuyo)  Mendoza Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7094-1031","authenticated-orcid":false,"given":"Gustavo Abel","family":"Abraham","sequence":"additional","affiliation":[{"name":"Instituto de Investigaciones en Ciencia y Tecnolog\u00eda de Materiales (INTEMA, CONICET\u2010Universidad Nacional de Mar del Plata)  Mar del Plata Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5837-3000","authenticated-orcid":false,"given":"Marina","family":"Uhart","sequence":"additional","affiliation":[{"name":"Instituto de Histolog\u00eda y Embriolog\u00eda de Mendoza (IHEM, CONICET\u2010Universidad Nacional de Cuyo)  Mendoza Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4997-7982","authenticated-orcid":false,"given":"Ana Agustina","family":"Aldana","sequence":"additional","affiliation":[{"name":"Instituto de Investigaciones en Ciencia y Tecnolog\u00eda de Materiales (INTEMA, CONICET\u2010Universidad Nacional de Mar del Plata)  Mar del Plata Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,4,22]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/adhm.201801578"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrm.2017.108"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev\u2010biophys\u2010062215\u2010011206"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.msec.2019.110415"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.1115\/1.4001945"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.3390\/nano10050887"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.3390\/nano9010120"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.1088\/1758\u20105090\/ab9988"},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/jbm.b.33876"},{"key":"e_1_2_12_11_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsami.9b12639"},{"key":"e_1_2_12_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bprint.2020.e00105"},{"key":"e_1_2_12_13_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10439\u2010019\u201002428\u20105"},{"key":"e_1_2_12_14_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12015\u2010019\u201009893\u20104"},{"key":"e_1_2_12_15_1","doi-asserted-by":"publisher","DOI":"10.1007\/s42242\u2010018\u20100028\u20108"},{"key":"e_1_2_12_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/adhm.201500005"},{"key":"e_1_2_12_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2010.03.064"},{"key":"e_1_2_12_18_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10856\u2010019\u20106302\u20102"},{"key":"e_1_2_12_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2018.02.049"},{"key":"e_1_2_12_20_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1618239114"},{"key":"e_1_2_12_21_1","doi-asserted-by":"publisher","DOI":"10.1002\/jbm.b.30128"},{"key":"e_1_2_12_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.msec.2017.04.084"},{"key":"e_1_2_12_23_1","doi-asserted-by":"publisher","DOI":"10.3389\/fcell.2018.00033"},{"key":"e_1_2_12_24_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcb.30128"},{"key":"e_1_2_12_25_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10856\u2010020\u201006434\u20101"},{"key":"e_1_2_12_26_1","doi-asserted-by":"publisher","DOI":"10.1002\/biot.202200413"},{"key":"e_1_2_12_27_1","doi-asserted-by":"publisher","DOI":"10.3390\/biomedicines10051177"},{"key":"e_1_2_12_28_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0154806"},{"key":"e_1_2_12_29_1","doi-asserted-by":"publisher","DOI":"10.1038\/s43586\u2010023\u201000278\u2010z"},{"key":"e_1_2_12_30_1","doi-asserted-by":"publisher","DOI":"10.3390\/polym11091424"},{"key":"e_1_2_12_31_1","doi-asserted-by":"publisher","DOI":"10.1177\/08839115221138777"},{"key":"e_1_2_12_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-12-822476-2.00010-8"},{"key":"e_1_2_12_33_1","doi-asserted-by":"publisher","DOI":"10.1002\/mame.202100115"},{"key":"e_1_2_12_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.polymertesting.2020.106647"},{"key":"e_1_2_12_35_1","doi-asserted-by":"publisher","DOI":"10.3390\/nano6040075"},{"key":"e_1_2_12_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.msec.2020.111787"},{"key":"e_1_2_12_37_1","doi-asserted-by":"publisher","DOI":"10.1038\/srep37960"},{"key":"e_1_2_12_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.colsurfb.2022.112724"}],"container-title":["Journal of Biomedical Materials Research Part A"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jbm.a.37914","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,6,16]],"date-time":"2025-06-16T14:17:09Z","timestamp":1750083429000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jbm.a.37914"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,4,22]]},"references-count":37,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2025,5]]}},"alternative-id":["10.1002\/jbm.a.37914"],"URL":"https:\/\/doi.org\/10.1002\/jbm.a.37914","archive":["Portico"],"relation":{},"ISSN":["1549-3296","1552-4965"],"issn-type":[{"value":"1549-3296","type":"print"},{"value":"1552-4965","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,4,22]]},"assertion":[{"value":"2024-12-13","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-04-07","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-04-22","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e37914"}}