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Despite this, the changes of the polymer structure and their effects on mechanical properties and degradation behavior caused by the additive manufacturing process and subsequent sterilization are still insufficiently investigated, although of key relevance for the implant's functionality. In this study, poly(p\u2010dioxanone) (PPDO) was processed by fused filament fabrication (FFF). The effects of manufacturing as well as two different low\u2010temperature sterilization techniques, namely H\n                    <jats:sub>2<\/jats:sub>\n                    O\n                    <jats:sub>2<\/jats:sub>\n                    plasma and gamma irradiation, on the polymer structure were evaluated. Additionally, PPDO degradation was investigated by immersing the processed samples in Sorensen's phosphate buffer (PB) with pH\u2009=\u20096.47 for 28\u2009days to mimic implantation in intestinal milieu and evaluated at regular time intervals. Results showed that we were able to successfully print\n                    <jats:styled-content style=\"fixed-case\">PPDO<\/jats:styled-content>\n                    without influencing the polymer structure or cytocompatibility. No significant changes were detected for plasma\u2010sterilized samples (\n                    <jats:styled-content style=\"fixed-case\">PS<\/jats:styled-content>\n                    ) while gamma\u2010sterilized (\n                    <jats:styled-content style=\"fixed-case\">GS<\/jats:styled-content>\n                    ) ones significantly decreased molecular weight (M\n                    <jats:sub>w<\/jats:sub>\n                    and M\n                    <jats:sub>n<\/jats:sub>\n                    ) and showed significant lower inherent viscosity (\n                    <jats:styled-content style=\"fixed-case\">IV<\/jats:styled-content>\n                    ) compared with the (non\u2010sterilized) control group after processing. During immersion in PB, a decrease in M\n                    <jats:sub>w<\/jats:sub>\n                    , M\n                    <jats:sub>n<\/jats:sub>\n                    , and mechanical strength occurred for all samples. However, GS samples were affected to a much higher extent compared with the other groups both in final values and timeline. A degradation plateau was seen for the tensile strength of NS and PS samples over the first 21 and 17\u2009days, respectively, followed by a steady decrease. In contrast, for the GS samples, a drastic decrease in tensile strength occurred already during the first 14\u2009days. There was no notable mass loss detected within the first 28\u2009days of degradation for any of the sample groups. Based on these results, we conclude that FFF with subsequent plasma sterilization is a reliable process for manufacturing PPDO devices for short\u2010term applications that require stable mechanical conditions within the first weeks of implantation to guarantee the time needed for tissue healing before degrading, as for example, in the case of intestinal compression anastomoses. Such requirement could not be met with gamma sterilization with the dose used, because of the too fast decrease in mechanical properties.\n                  <\/jats:p>","DOI":"10.1002\/jbm.a.37957","type":"journal-article","created":{"date-parts":[[2025,7,5]],"date-time":"2025-07-05T00:11:32Z","timestamp":1751674292000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Effects of Additive Manufacturing and Sterilization on Poly(p\u2010Dioxanone) for Short\u2010Term Application in the Intestinal Environment"],"prefix":"10.1002","volume":"113","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0491-5796","authenticated-orcid":false,"given":"Stefanie","family":"Ficht","sequence":"first","affiliation":[{"name":"Technical University of Munich, TUM School of Engineering and Design, Department of Mechanical Engineering, Chair of Medical Materials and Implants, Munich Institute of Biomedical Engineering (MIBE)  Munich 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