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Yet, post\u2010surgical failure of coated orthopedic implants occurs due to poor adhesive strength, fatigue failure, high wear rate of coated materials, low biocompatibility, limited osseointegration, and stress\u2010shielding effect. Therefore, there is an unmet clinical need to develop a smart coating strategy. Herein, we have created an electrospun nanofibrous coating for Ti\u2010implants using piezoelectric Polyvinylidene fluoride (PVDF) polymer reinforced with osteoconductive nanofiller Zinc oxide (ZnO). We have found that by varying the ZnO content from 0.5 to 2.0\u2009wt.% in the PVDF matrix, we can modulate the electrospun coating's mechanical, thermal, physicochemical stability, and piezoelectric characteristics. Our results proved that PVDF\u2010ZnO nanofibrous coatings exhibit almost ~3\u20134 fold increase in the piezoelectric d<jats:sub>33<\/jats:sub> coefficient as well as output voltage, compared to pure PVDF using Piezo\u2010responsive Force Microscopy (PFM). Furthermore, electrically poled piezoelectric PVDF\u2010ZnO nanofibers also demonstrated a significant increment (~5\u2010fold) in collagen deposition, hydroxyapatite formation, and improved bio\u2010 and hemo\u2010compatibility compared to unpoled nanofibers. Furthermore, through the in\u00a0vitro experiments, we have confirmed that the piezoelectric PVDF\u2010ZnO nanofibrous activates calcium\u2010calmodulin mediated cellular pathway to induce cell adhesion, proliferation, and cell spreading in the osteoblast cells. Nonetheless, using the biomimetic mechanical bioreactor, we have investigated the piezoelectricity\u2010mediated increased focal adhesion and enhanced F\u2010actin production under the physiologically relevant (i.e., 1%) mechanical strain in bone cells. Moreover, the current study elucidates the piezoelectric\u2010based smart, multifunctional coating strategies for developing an osteoconductive implant.<\/jats:p>","DOI":"10.1002\/jbm.a.37971","type":"journal-article","created":{"date-parts":[[2025,8,8]],"date-time":"2025-08-08T12:05:27Z","timestamp":1754654727000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Bioactive <scp>ZnO<\/scp> Decorated <scp>PVDF<\/scp>\u2010Based Piezoelectric, Osteoconductive Nanofibrous Coatings for Orthopedic Implants"],"prefix":"10.1002","volume":"113","author":[{"given":"Sumedh","family":"Vaidya","sequence":"first","affiliation":[{"name":"Department of Medical Devices National Institute of Pharmaceutical Education and Research\u2010Ahmedabad  Gandhinagar Gujarat India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mansi","family":"Joshi","sequence":"additional","affiliation":[{"name":"Department of Medical Devices 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