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Stromal cell\u2010derived factor\u20101a (SDF\u20101a) modulates progenitor cell recruitment to neural injury sites and may contribute to neural repair. However, SDF\u20101a has a short half\u2010life and requires a delivery system to both protect and sustain its release. Here, we sought to develop a drug delivery platform capable of releasing SDF\u20101a in a controlled fashion while minimizing inflammation. We used modified hyaluronic acid and microfluidics to generate monodisperse microgels. Characterization of these microgels included size, tunability, degradation, and controlled release properties. Finally, we delivered SDF\u20101a\u2010loaded microgels to a mouse model of traumatic brain injury at 7\u2009days post\u2010injury and assessed their impact on neural progenitor cell recruitment and astrogliosis<jats:italic>.<\/jats:italic> The microfluidic system generated highly monodisperse microgels that successfully encapsulated a matrix metalloproteinase (MMP)\u2010cleavable SDF\u20101a peptide and retained sensitivity to collagenase. Following intracortical injections, the microgels did not exacerbate the astrocytic response compared to saline injections; no significant difference was observed in neural progenitor cell migration patterns compared to controls. Therefore, we developed a biocompatible microgel system that is highly adaptable for biological delivery and may be utilized in brain\/neural applications without exacerbating neuroinflammation.<\/jats:p>","DOI":"10.1002\/jbm.a.37972","type":"journal-article","created":{"date-parts":[[2025,8,11]],"date-time":"2025-08-11T12:00:32Z","timestamp":1754913632000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Development and Characterization of Hyaluronic Acid Microgels for Neural Regeneration Applications"],"prefix":"10.1002","volume":"113","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3133-5714","authenticated-orcid":false,"given":"Kassondra N.","family":"Hickey","sequence":"first","affiliation":[{"name":"School of Biological and Health Systems Engineering, Arizona State University  Tempe Arizona USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shannon 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