{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T12:25:37Z","timestamp":1789647937696,"version":"4.0.0"},"reference-count":67,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2025,9,3]],"date-time":"2025-09-03T00:00:00Z","timestamp":1756857600000},"content-version":"vor","delay-in-days":2,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100003787","name":"Natural Science Foundation of Hebei Province","doi-asserted-by":"publisher","award":["H2020103010"],"award-info":[{"award-number":["H2020103010"]}],"id":[{"id":"10.13039\/501100003787","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Biomedical Materials Res"],"published-print":{"date-parts":[[2025,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    This study investigated the therapeutic effects of a composite small intestinal submucosa decellularized extracellular matrix\/hyaluronic acid (HA)\u2010incorporated thermosensitive hydrogel (HA\u2010Gel) on interstitial cystitis (IC) in rats. The HA\u2010Gel was fabricated using rabbit small intestinal submucosa\u2010derived extracellular matrix as a thermosensitive scaffold combined with HA, and an IC rat model was established using the UPK3A65\u201384 peptide. Rats were divided into five groups: IC group, IC\u2009+\u2009HA group, IC\u2009+\u2009Gel group, IC\u2009+\u2009HA\u2010Gel group, and a non\u2010modeled control group. After 14\u2009days of treatment, urodynamic analysis revealed that the HA, IC\u2009+\u2009Gel, and IC\u2009+\u2009HA\u2010Gel groups exhibited significantly increased interval voiding times and maximum bladder capacities compared to the IC group, with the most pronounced improvement observed in the IC\u2009+\u2009HA\u2010Gel group (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.01). Histopathological evaluation revealed reduced mucosal edema, inflammatory cell infiltration, and mucosal denudation in all treatment groups, particularly in the IC\u2009+\u2009HA\u2010Gel group (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.01). Mast cell infiltration was also markedly suppressed by HA\u2010Gel (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.01). Immunofluorescence and molecular analyses further indicated that HA, Gel, and HA\u2010Gel effectively downregulated the expression levels of CD3, ICAM\u20101, TNF\u2010\u03b1, IFN\u2010\u03b3, IL\u20101\u03b2, IL\u20106, and TRPM8 in bladder tissues, with the most significant reductions observed in the IC\u2009+\u2009HA\u2010Gel group (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.01). Notably, both Gel and HA\u2010Gel remained detectable in bladder tissues for over 14\u2009days post\u2010administration. In conclusion, HA\u2010Gel not only improves voiding function and bladder capacity in IC rats but also suppresses inflammatory responses, demonstrating promising therapeutic potential and providing new insights for the clinical management of IC\/bladder pain syndrome (BPS).\n                  <\/jats:p>","DOI":"10.1002\/jbm.a.37973","type":"journal-article","created":{"date-parts":[[2025,9,3]],"date-time":"2025-09-03T11:23:43Z","timestamp":1756898623000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Therapeutic Effect of a Composite Acellular Matrix\/Hyaluronic Acid Thermosensitive Hydrogel for the Interstitial Cystitis\/Bladder Pain Syndrome in a Rat Model"],"prefix":"10.1002","volume":"113","author":[{"given":"Haichao","family":"Liu","sequence":"first","affiliation":[{"name":"Department of Urology, China Rehabilitation Research Center, Beijing Boai Hospital School of Rehabilitation of Capital Medical University  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7035-5611","authenticated-orcid":false,"given":"Wei","family":"Guo","sequence":"additional","affiliation":[{"name":"Department of Urology, China Rehabilitation Research Center, Beijing Boai Hospital School of Rehabilitation of Capital Medical University  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianzhong","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Urology, Beijing Friendship Hospital Capital Medical University  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Tang","sequence":"additional","affiliation":[{"name":"Department of Urology Hebei Yanda Hospital  Langfang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fei","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Urology, Beijing Chaoyang Hospital Capital 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