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Endoscopic spring placement would minimize the morbidity associated with device insertion. This study investigates the use of submucosal injection of engineered hydrogel to temporarily confine a compressed spring within an intestinal segment. Engineered hydrogels were composed of hyaluronic acid (HA) alone or HA with elastin\u2010like protein (HELP). To simulate endoscopic injection in six juvenile pigs, hydrogel was injected into the submucosa in everted jejunum, followed by the placement of a gelatin\u2010encapsulated, compressed nitinol spring. The jejunum was then unfolded over the spring, and hydrogel was injected distally into the submucosa. Sutures were placed as fiducial markers. After 7\u2009days on a liquid diet, the pigs were euthanized, and their intestinal segments were analyzed for lengthening and histological changes. The spring\u2010containing jejunal segments expanded in all animals, lengthening to 132% in the HA group and 188% in the HELP group. HELP hydrogels exhibited slower biodegradation than HA\u2010only hydrogels. Histological analysis showed increased crypt width and decreased crypt density in the spring\u2010containing segments compared to controls. Hydrogel effectively provides temporary spring confinement within intestinal segments without adverse effects. The mechanical stimulation from the spring induces crypt fission, expanding the intestinal epithelium. These results support the feasibility of gel\u2010enabled, spring\u2010mediated distraction enterogenesis for intestinal lengthening.<\/jats:p>","DOI":"10.1002\/jbm.a.37986","type":"journal-article","created":{"date-parts":[[2025,9,22]],"date-time":"2025-09-22T11:02:07Z","timestamp":1758538927000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Submucosal Hydrogel for Spring\u2010Mediated Intestinal Lengthening"],"prefix":"10.1002","volume":"113","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7613-1398","authenticated-orcid":false,"given":"Fereshteh","family":"Salimi\u2010Jazi","sequence":"first","affiliation":[{"name":"Division of Pediatric Surgery, Department of Surgery Stanford University School of Medicine  Stanford California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Narelli","family":"de Paiva Narciso","sequence":"additional","affiliation":[{"name":"Department of Materials Science and Engineering Stanford University  Stanford California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gillian","family":"Fell","sequence":"additional","affiliation":[{"name":"Division of Plastic Surgery, Department of Surgery Stanford University School of Medicine  Stanford California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne\u2010Laure","family":"Thomas","sequence":"additional","affiliation":[{"name":"Division of Pediatric Surgery, Department of Surgery Stanford University School of Medicine  Stanford California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Renato S.","family":"Navarro","sequence":"additional","affiliation":[{"name":"Department of Materials Science and Engineering Stanford University  Stanford California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Talha","family":"Rafeeqi","sequence":"additional","affiliation":[{"name":"Division of Pediatric Surgery, Department of Surgery Stanford University School of Medicine  Stanford California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Neil J.","family":"Baugh","sequence":"additional","affiliation":[{"name":"Department of Materials Science and Engineering Stanford University  Stanford California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Riley A.","family":"Suhar","sequence":"additional","affiliation":[{"name":"Department of Materials Science and Engineering Stanford University  Stanford California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julie\u2010Ann","family":"Nguyen","sequence":"additional","affiliation":[{"name":"Division of Pediatric Surgery, Department of Surgery Stanford University School of Medicine  Stanford California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nolan","family":"Lopez","sequence":"additional","affiliation":[{"name":"Division of Pediatric Surgery, Department of Surgery Stanford University School of Medicine  Stanford California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarah C.","family":"Heilshorn","sequence":"additional","affiliation":[{"name":"Department of Materials Science and Engineering Stanford University  Stanford California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James C. 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