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This study focuses on the fabrication of porous core\u2013shell microparticles encapsulating bioactive telodendrimer (TD) nanodrug carriers using electrospray technology. The microparticles were designed to enhance pulmonary drug delivery by optimizing particle size (1\u20135\u2009\u03bcm) and morphology for deep lung deposition and controlled drug release. The effects of solution viscosity and surface tension on microparticle formation were systematically investigated. Results demonstrated that higher polymer concentration and controlled electrospray parameters yielded spherical microparticles with uniform porosity, essential for sustained drug release. Surfactant addition reduced particle size and enhanced pore formation but introduced challenges such as morphological variability. In\u00a0vitro cytotoxicity, hemolysis, and drug release studies confirmed the biocompatibility and therapeutic potential of the fabricated microparticles. The findings highlight the promise of electrospray\u2010derived core\u2013shell microparticles for non\u2010invasive COPD treatment, warranting further exploration into polymer\u2010solvent interactions and formulation refinements for optimized drug delivery.<\/jats:p>","DOI":"10.1002\/jbm.a.37987","type":"journal-article","created":{"date-parts":[[2025,9,12]],"date-time":"2025-09-12T14:49:09Z","timestamp":1757688549000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Coaxial Electrospray of Nanodrug\u2010Loaded Porous Polylactic Acid\/Poly(Ethylene Oxide) Core\u2013Shell Microparticles for Intrapulmonary Drug Delivery"],"prefix":"10.1002","volume":"113","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7430-9057","authenticated-orcid":false,"given":"Chi","family":"Wang","sequence":"first","affiliation":[{"name":"Systems Science and Industrial Engineering Binghamton University  Binghamton New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dandan","family":"Guo","sequence":"additional","affiliation":[{"name":"Department of Pharmacology SUNY Upstate Medical University  Syracuse New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juntao","family":"Luo","sequence":"additional","affiliation":[{"name":"Department of Pharmacology SUNY Upstate Medical University  Syracuse New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7278-480X","authenticated-orcid":false,"given":"Yingge","family":"Zhou","sequence":"additional","affiliation":[{"name":"Systems Science and Industrial Engineering Binghamton University  Binghamton New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,9,12]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.3390\/scipharm87030020"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrd.2018.183"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.2147\/DDDT.S287323"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1615\/CritRevTherDrugCarrierSyst.2016015798"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.drudis.2014.01.012"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cis.2018.02.002"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.addr.2014.05.008"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.4155\/tde-2017-0037"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1080\/02786826.2020.1849536"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1208\/s12249-020-01675-3"},{"key":"e_1_2_7_12_1","first-page":"741","article-title":"Development and Evaluation of Aerodynamic Particle Size Distribution of Inhalable Spray Dried Rifampicin Loaded Steric Acid\u2010Chitosan Nanomicellar Micro\u2010Composites Dry Powder Inhaler by Qbd Approach With Dual Analysis by TSI\/ACI Deposition Study","volume":"14","author":"Mali A. 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