{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,19]],"date-time":"2026-10-19T17:12:04Z","timestamp":1792429924496,"version":"4.5.0"},"reference-count":44,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2025,9,22]],"date-time":"2025-09-22T00:00:00Z","timestamp":1758499200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,9,22]],"date-time":"2025-09-22T00:00:00Z","timestamp":1758499200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100000001","name":"National Science Foundation","doi-asserted-by":"publisher","award":["2138587"],"award-info":[{"award-number":["2138587"]}],"id":[{"id":"10.13039\/100000001","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Biomedical Materials Res"],"published-print":{"date-parts":[[2025,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Hydrogels that combine mechanical tunability with biochemical relevance are essential for engineering tissue\u2010mimetic scaffolds for tissue engineering and regenerative medicine applications. In this study, we present for the first time a tunable hydrogel platform formed via Diels\u2013Alder bioorthogonal click chemistry using furan\u2010functionalized hyaluronic acid (HA\u2010furan), furan\u2010functionalized type I collagen (Col\u2010furan), and bis\u2010maleimide\u2010functionalized polyethylene glycol (mal\u2010PEG\u2010mal). Hydrogels were fabricated at furan:maleimide molar ratios of 1:0.5, 1:1, and 1:2.5 and gelled under physiological conditions for 24\u2009h without the need for catalysts or initiators. Material characterization revealed that this mechanism fabricated predominantly elastic hydrogels, where the 1:1\u2009M ratio hydrogel was the most stable and had the highest mechanical properties, with a Young's modulus that was 2.1\u2010fold and 4.7\u2010fold larger than the 1:0.5 and 1:2.5\u2009M ratio hydrogels, respectively. Further analysis revealed that hydrogel stability and performance were predominantly controlled by hydrogel structure (amorphous vs. crystalline) and crosslinking density. This enhanced mechanical stability and performance were also synergized with enhanced bioactivity from the incorporation of Col, which introduced native Arg\u2010Gly\u2010Asp (RGD) motifs that support cell interactions. Overall, this bioactive yet biomechanically stable hydrogel system provides a tunable platform for engineering extracellular matrix\u2010inspired biomaterials with broad potential for soft tissue repair and regenerative medicine applications.<\/jats:p>","DOI":"10.1002\/jbm.a.37992","type":"journal-article","created":{"date-parts":[[2025,9,22]],"date-time":"2025-09-22T10:48:07Z","timestamp":1758538087000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Hyaluronic Acid\/Type I Collagen Hydrogels With Tunable Physicochemical Properties Using Diels\u2013Alder Click Chemistry"],"prefix":"10.1002","volume":"113","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9043-1207","authenticated-orcid":false,"given":"Rabia","family":"Fatima","sequence":"first","affiliation":[{"name":"Department of Chemical and Biomolecular Engineering Clarkson University  Potsdam New York 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