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Targeting cellular senescence and its associated inflammatory microenvironment presents a promising strategy for mitigating osteoporosis progression. Glycyrrhizic acid (GA), a naturally occurring triterpenoid, has been shown to alleviate cellular senescence in various age\u2010related disorders. Herein, injectable GA\/gelatin methacrylate hydrogel microspheres (GA@GelMA) were developed using microfluidic technology to enable sustained GA release. The microspheres demonstrated multiple functionalities in\u00a0vitro, including suppression of cellular senescence, induction of M1\u2010to\u2010M2 macrophage polarization, and enhancement of osteogenic differentiation in bone marrow stem cells (BMSCs). In an ovariectomized (OVX) mouse model of osteoporosis, local administration of GA@GelMA microspheres significantly promoted bone formation and alleviated the senescence\u2010associated inflammatory microenvironment. These GA@GelMA microspheres provide a multifunctional strategy integrating osteogenesis promotion and senescence modulation for the treatment of osteoporosis.<\/jats:p>","DOI":"10.1002\/jbm.a.38016","type":"journal-article","created":{"date-parts":[[2025,11,11]],"date-time":"2025-11-11T09:41:21Z","timestamp":1762854081000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Injectable Glycyrrhizic Acid Hydrogel Microspheres With Synergistic Anti\u2010Senescence and Osteogenic Effects for Osteoporosis Therapy"],"prefix":"10.1002","volume":"113","author":[{"given":"Yunchen","family":"Hong","sequence":"first","affiliation":[{"name":"Department of Spinal Surgery Jiangdu People's Hospital Affiliated With Yangzhou University, Yangzhou University  Yangzhou P. R. China"},{"name":"Department of Orthopedics Affiliated Hospital of Yangzhou University  Yangzhou P. R. 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