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Current therapies primarily target late\u2010stage symptoms and are limited by their frequent and invasive intravitreal (IVT) injections. To address oxidative stress\u2010induced inflammation mechanisms relevant to early retinal degeneration, we developed a heme\u2010bound human serum albumin (heme\u2010albumin) complex designed to transiently induce heme oxygenase\u20101 (HO\u20101), a cytoprotective enzyme with antioxidant and anti\u2010inflammatory effects. Polydopamine nanoparticles (PDA NPs) were selected as a delivery system due to their ability to scavenge reactive oxygen species (ROS) and degrade under oxidative environments. A previous in\u00a0vitro study demonstrated that heme\u2010albumin\u2010loaded PDA NPs reduce oxidative damage and inflammatory signaling in retinal pigment epithelium (RPE) cells. This study evaluates the in\u00a0vivo biocompatibility of IVT\u2010administered heme\u2010albumin and unloaded PDA NPs as independent components in a murine model. At the tested doses, both components showed minimal cytotoxicity with preservation of retinal structure, establishing biocompatible dosing for future evaluation in retinal disease models.<\/jats:p>","DOI":"10.1002\/jbm.a.70058","type":"journal-article","created":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T14:15:44Z","timestamp":1772979344000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Murine Biocompatibility Evaluation of an Albumin\u2010Derived Complex and Nanoparticle Delivery System for Ocular Applications"],"prefix":"10.1002","volume":"114","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2701-4547","authenticated-orcid":false,"given":"Amna","family":"Abdalbaqi","sequence":"first","affiliation":[{"name":"William G. 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