{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,27]],"date-time":"2026-06-27T13:49:32Z","timestamp":1782568172312,"version":"3.54.5"},"reference-count":43,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2026,3,23]],"date-time":"2026-03-23T00:00:00Z","timestamp":1774224000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,3,23]],"date-time":"2026-03-23T00:00:00Z","timestamp":1774224000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Biomedical Materials Res"],"published-print":{"date-parts":[[2026,4]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Effective skin wound healing requires reliable fixation and infection prevention. Inspired by the inclined papillary structure of the tiger's tongue, we developed a biomimetic microneedle patch that integrates mechanical stability with antibacterial function. The patch was fabricated via thermal pressing of polylactic acid (PLA) microneedles followed by localized drug loading at the microneedle tips. Its design includes a clamping structure, a dual\u2010array of inclined drug\u2010releasing PLA microneedles, a nonwoven fabric base, and a flexible adhesive layer. In\u00a0vitro tests demonstrated a penetration force of 0.25\u2009N, enhanced fixation through biomimetic interlocking, and controlled drug release for antibacterial effects. In\u00a0vivo studies using a male Wistar rat model showed that the patch secured wounds, reduced inflammation, and promoted collagen deposition. These results demonstrate that this drug\u2010loaded biomimetic microneedle patch promotes the healing of full\u2010thickness skin wounds and exhibits superior efficacy compared to drug\u2010free biomimetic microneedle treatments. This study advances wound care by combining biomechanical and pharmacological strategies. Future work will optimize biocompatibility and explore clinical applications.<\/jats:p>","DOI":"10.1002\/jbm.a.70062","type":"journal-article","created":{"date-parts":[[2026,3,23]],"date-time":"2026-03-23T14:14:53Z","timestamp":1774275293000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Tiger Tongue\u2010Inspired Bionic Microneedle Patch With Dual Mechanical\u2010Pharmacological Functions for Enhanced Wound Healing"],"prefix":"10.1002","volume":"114","author":[{"ORCID":"https:\/\/orcid.org\/0009-0004-7320-7229","authenticated-orcid":false,"given":"Yangguang","family":"Niu","sequence":"first","affiliation":[{"name":"School of Ocean Information Engineering Jimei University  Xiamen China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingyuan","family":"Ren","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Vaccines for Infectious Diseases, Xiangan Biomedicine Laboratory, State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics, National Innovation Platform for Industry\u2010Education Integration in Vaccine Research, School of Public Health Xiamen University  Xiamen China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kangxun","family":"Zhao","sequence":"additional","affiliation":[{"name":"School of Ocean Information Engineering Jimei University  Xiamen China"},{"name":"Xiamen Weizhen Pharmaceutical Technology Co., Ltd  Xiamen China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tianqi","family":"Ma","sequence":"additional","affiliation":[{"name":"School of Ocean Information Engineering Jimei University  Xiamen China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanting","family":"Wang","sequence":"additional","affiliation":[{"name":"School of Ocean Information Engineering Jimei University  Xiamen China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xin","family":"Chen","sequence":"additional","affiliation":[{"name":"Xiamen Weizhen Pharmaceutical Technology Co., Ltd  Xiamen China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chenhui","family":"Zheng","sequence":"additional","affiliation":[{"name":"Xiamen Weizhen Pharmaceutical Technology Co., Ltd  Xiamen China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lijuan","family":"Chen","sequence":"additional","affiliation":[{"name":"Xiamen Weizhen Pharmaceutical Technology Co., Ltd  Xiamen China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yingting","family":"Li","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Vaccines for Infectious Diseases, Xiangan Biomedicine Laboratory, State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics, National Innovation Platform for Industry\u2010Education Integration in Vaccine Research, School of Public Health Xiamen University  Xiamen China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoping","family":"Cao","sequence":"additional","affiliation":[{"name":"The First Hospital of Longyan City  Longyan China"},{"name":"Jiangsu Weizhen Pharmaceutical Technology Co., Ltd  Suzhou Jiangsu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1165-2472","authenticated-orcid":false,"given":"Ling","family":"Xu","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Vaccines for Infectious Diseases, Xiangan Biomedicine Laboratory, State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics, National Innovation Platform for Industry\u2010Education Integration in Vaccine Research, School of Public Health Xiamen University  Xiamen China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9655-3256","authenticated-orcid":false,"given":"Xueqiu","family":"You","sequence":"additional","affiliation":[{"name":"School of Ocean Information Engineering Jimei University  Xiamen China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,3,23]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/prd.12546"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/adhm.202404255"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1055\/a\u20102491\u20103631"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/wrr.13239"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/iwj.14581"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.actbio.2024.05.036"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/adfm.202207306"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/os.14217"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13017\u2010024\u201000566\u20103"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jor.2024.11.020"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1088\/1758\u20105090\/adacaf"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jksus.2024.103435"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.addr.2024.115217"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11706\u2010024\u20100689\u20105"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1039\/D4MA00234B"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.3390\/pharmaceutics16030300"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.1039\/D4NR03538K"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.2147\/CCID.S492774"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bea.2024.100127"},{"key":"e_1_2_11_21_1","doi-asserted-by":"publisher","DOI":"10.1055\/s\u20100043\u20101777440"},{"key":"e_1_2_11_22_1","doi-asserted-by":"publisher","DOI":"10.1002\/adma.202310110"},{"key":"e_1_2_11_23_1","doi-asserted-by":"publisher","DOI":"10.1039\/D3BM01551C"},{"key":"e_1_2_11_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bioactmat.2022.03.034"},{"key":"e_1_2_11_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.giant.2024.100261"},{"key":"e_1_2_11_26_1","doi-asserted-by":"publisher","DOI":"10.3390\/ph16030454"},{"key":"e_1_2_11_27_1","doi-asserted-by":"publisher","DOI":"10.1039\/D4RA00410H"},{"key":"e_1_2_11_28_1","doi-asserted-by":"publisher","DOI":"10.1002\/adhm.202401211"},{"key":"e_1_2_11_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccr.2024.216205"},{"key":"e_1_2_11_30_1","doi-asserted-by":"publisher","DOI":"10.1039\/D4NR04774E"},{"key":"e_1_2_11_31_1","doi-asserted-by":"publisher","DOI":"10.1002\/smmd.137"},{"key":"e_1_2_11_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijpharm.2024.123856"},{"key":"e_1_2_11_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eurpolymj.2023.112702"},{"key":"e_1_2_11_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.matlet.2025.138787"},{"key":"e_1_2_11_35_1","doi-asserted-by":"publisher","DOI":"10.1039\/D2BM00281G"},{"key":"e_1_2_11_36_1","doi-asserted-by":"publisher","DOI":"10.1208\/s12249\u2010023\u201002505\u2010y"},{"key":"e_1_2_11_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijbiomac.2024.129997"},{"key":"e_1_2_11_38_1","doi-asserted-by":"publisher","DOI":"10.1002\/adfm.202422602"},{"key":"e_1_2_11_39_1","doi-asserted-by":"publisher","DOI":"10.1038\/srep07914"},{"key":"e_1_2_11_40_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.msec.2014.06.021"},{"key":"e_1_2_11_41_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10544\u2010023\u201000658\u2010y"},{"key":"e_1_2_11_42_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jddst.2025.107165"},{"key":"e_1_2_11_43_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bioactmat.2023.04.003"},{"key":"e_1_2_11_44_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.actbio.2021.12.017"}],"container-title":["Journal of Biomedical Materials Research Part A"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jbm.a.70062","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/jbm.a.70062","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jbm.a.70062","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,6,27]],"date-time":"2026-06-27T13:37:19Z","timestamp":1782567439000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jbm.a.70062"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,3,23]]},"references-count":43,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2026,4]]}},"alternative-id":["10.1002\/jbm.a.70062"],"URL":"https:\/\/doi.org\/10.1002\/jbm.a.70062","archive":["Portico"],"relation":{},"ISSN":["1549-3296","1552-4965"],"issn-type":[{"value":"1549-3296","type":"print"},{"value":"1552-4965","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,3,23]]},"assertion":[{"value":"2025-10-28","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-02-24","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-03-23","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70062"}}