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In the present study, a multiple biofunctional self\u2010assembling hydrogels\u2010FGFP\/TIMP\u2010AMP was constructed, which comprised three key components: (1) a basic fibroblast growth factor\u2010mimetic peptide (FGFP), (2) an angiopoietin\u20101\u2010mimetic peptide (AMP), and (3) a microenvironment\u2010responsive TIMP sequence designed to target MMP\u20102. The FGFP\/TIMP\u2010AMP could assemble into a hydrogel under physiological conditions with a suitable pore size for cell growth. In\u00a0vitro, it significantly promoted HUVEC migration and tube formation. Using a PC12 deprivation of oxygen and glucose (OGD) model, it effectively reduced apoptosis and protected against hypoxia. Furthermore, the bFGF\/TIMP\u2010AMP assembling hydrogels enhanced neuronal survival, vascular regeneration, and blood\u2013brain barrier (BBB) repair in a middle cerebral artery occlusion (MCAO) rat model. These morphological improvements further promoted the recovery of motor function in behavioral tests. Therefore, these results highlighted the therapeutic potential of FGFP\/TIMP\u2010AMP assembling hydrogel for the repair of ischemic stroke.<\/jats:p>","DOI":"10.1002\/jbm.a.70063","type":"journal-article","created":{"date-parts":[[2026,3,23]],"date-time":"2026-03-23T14:17:47Z","timestamp":1774275467000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Self\u2010Assembling Hydrogel for Controlled Release of\n                    <scp>bFGF<\/scp>\n                    and Ang\u20101 Mimetic Peptide Promotes Neurovascular Repair in Ischemic Stroke Rats"],"prefix":"10.1002","volume":"114","author":[{"given":"Ange","family":"Nie","sequence":"first","affiliation":[{"name":"School of Clinical Medicine, Shandong Second Medical University  Weifang Shandong Province China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weihong","family":"Nie","sequence":"additional","affiliation":[{"name":"Department of Human 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