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Various types of antiadhesive materials, including films, solutions, and hydrogels, have been developed; however, they have limitations in providing localized antiadhesive properties, maintaining low volume change, and allowing for rapid preparation suitable for minimally invasive procedures. Here, we developed in\u00a0situ\u2010forming hydrogel barriers based on decanoyl group\u2010modified Alaska pollock gelatin (C10\u2010am\u2010ApGltn) and a poly(ethylene glycol)\u2010based crosslinker (4S\u2010PEG). The resulting hydrogels adhered to the desired intestinal tissue surfaces and showed antiadhesive property within 60\u2009s. The hydrogel barriers that adhered to the tissue were stable for at least 2\u2009days in an aqueous environment. The hydrogel barrier prepared from 4\u2009w\/v% C10\u2010ApGltn showed no volume changes after immersion in saline for 24\u2009h. The gelation time of the hydrogel was within 4\u2009s when the concentration of C10\u2010ApGltn ranged from 4 to 15\u2009w\/v%; however, it slowed at 2\u2009w\/v%. The freeze\u2010dried 4\u2009w\/v% C10\u2010am\u2010ApGltn sample rapidly dissolved in a buffer solution within a few min without heating. Furthermore, 4S\u2010PEG for 4\u2009w\/v% C10\u2010am\u2010ApGltn sample dissolved within 3\u2009s. An in\u00a0vivo rat adhesion model revealed that the hydrogel barrier of 4\u2009w\/v% C10\u2010ApGltn showed antiadhesive property, complete degradation behavior, and wound healing property within 2\u2009weeks. With its antiadhesive effects, stable volume, and short preparation time, the hydrogel barrier developed from 4\u2009w\/v% C10\u2010am\u2010ApGltn has the potential to be used as a localized barrier for the prevention of postoperative adhesion.<\/jats:p>","DOI":"10.1002\/jbm.a.70064","type":"journal-article","created":{"date-parts":[[2026,4,11]],"date-time":"2026-04-11T06:51:11Z","timestamp":1775890271000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Localized Antiadhesive Hydrogel Barriers for Prevention of Postoperative Adhesion"],"prefix":"10.1002","volume":"114","author":[{"given":"Hiyori","family":"Komatsu","sequence":"first","affiliation":[{"name":"Graduate School of Science and Technology, Degree Programs in Pure and Applied Sciences, University of Tsukuba  Tsukuba Ibaraki Japan"},{"name":"Biomaterials Field, Research Center for Macromolecules and Biomaterials National Institute for Materials Science  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