{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,25]],"date-time":"2026-07-25T18:01:26Z","timestamp":1785002486607,"version":"3.55.0"},"reference-count":60,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Biomedical Materials Res"],"published-print":{"date-parts":[[2026,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Thermoresponsive poloxamers are commonly used in biomedical applications; however, their wider translational applicability depends on precisely controlling sol\u2013gel transition behavior near body temperature while ensuring injectability and a favorable biocompatibility profile. In this study, blends of three clinically relevant poloxamers were evaluated to find formulations suitable for potential injectable meniscal and joint therapies. The rheological properties and temperature\u2010dependent gelation of these formulations were characterized, followed by testing their injectability into meniscal defects and assessing biological responses in\u00a0vitro. The gelation temperatures reported in this work were operationally defined from viscosity\u2010based temperature sweep measurements. Biocompatibility, cell viability, and migration of outer fibrochondrocytes exposed to selected poloxamer hydrogels were examined to gauge their potential for orthopedic applications. Different material behaviors emerged based on polymer composition. Synperonic F\u2010108 combined with Poloxamer 188 showed decreased adhesiveness and aggregation, along with maintained cell viability after prolonged incubation, indicating potential as a coating material or a general structural matrix. Conversely, blends of Kolliphor K 407 with Poloxamer 188 displayed temperature\u2010dependent increases in viscosity. They formed stable gels at body temperature, maintaining a favorable biological response in direct\u2010contact conditions, which supports their further evaluation in long\u2010term injectable applications with controlled structural stability. These results show that careful selection and optimization of poloxamer blends allow tailoring material properties for specific biomedical functions. The adjustable thermoresponsive behavior, chemical inertness, and simple preparation of these triblock copolymers make them practical for further development in injectable biomaterials and drug delivery systems for osteoarticular repair.<\/jats:p>","DOI":"10.1002\/jbm.a.70097","type":"journal-article","created":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T14:58:01Z","timestamp":1782917881000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Tunable Sol\u2013Gel Transition in Poloxamer Blends for Injectable Osteoarticular Applications"],"prefix":"10.1002","volume":"114","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0841-9220","authenticated-orcid":false,"given":"Marta","family":"Tuszynska","sequence":"first","affiliation":[{"name":"Department of Oncology, Ludwik Rydygier Collegium Medicum in Bydgoszcz Nicolaus Copernicus University in Torun  Bydgoszcz 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