{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,4]],"date-time":"2026-06-04T08:02:15Z","timestamp":1780560135412,"version":"3.54.1"},"reference-count":45,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2026,6,4]],"date-time":"2026-06-04T00:00:00Z","timestamp":1780531200000},"content-version":"vor","delay-in-days":3,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100006249","name":"Donghua University","doi-asserted-by":"publisher","award":["2232023D\u201009"],"award-info":[{"award-number":["2232023D\u201009"]}],"id":[{"id":"10.13039\/501100006249","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Biomedical Materials Res"],"published-print":{"date-parts":[[2026,6]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Electrospun nanofiber membranes hold promise for abdominal wall repair due to their biomimetic architecture and tunable properties. However, their porous structure often induces an elevated foreign body response (FBR) that impedes tissue integration and remodeling. While previous strategies have employed ibuprofen (IBU) to mitigate inflammation, its non\u2010selective cyclooxygenase (COX) inhibition and rapid systemic clearance limit local therapeutic efficacy. Herein, we functionalized electrospun polylactic acid (PLA)\/gelatin (Gel) nanofiber\u2010bundle membranes with chitosan (CS) and loxoprofen (LOX), a prodrug\u2010type nonsteroidal anti\u2010inflammatory drug with enhanced tissue penetration and cyclooxygenase\u20102 (COX\u20102) selectivity to achieve sustained local immunomodulation while preserving membrane porosity. The PLA\/Gel\u2010CS\u2010LOX membrane exhibited favorable physicochemical properties, sustained LOX release over 28\u2009days, and potent antibacterial activity. It showed good cytocompatibility and downregulated pro\u2010inflammatory genes and upregulated anti\u2010inflammatory genes of LPS\u2010stimulated macrophages, and significantly reduced oxygen species (ROS) production. In a rat full\u2010thickness abdominal wall defect model, the PLA\/Gel\u2010CS\u2010LOX membrane facilitated robust cell infiltration, angiogenesis, and tissue integration. At 90\u2009days post\u2010implantation, regenerated tissues exhibited mechanical properties comparable to native abdominal wall, with optimized collagen remodeling evidenced by balanced matrix metalloproteinase 9 (MMP9)\/tissue inhibitor of metalloproteinase 1 (TIMP1) expression. These results demonstrate that CS\u2010LOX functionalization represents a promising strategy to modulate inflammatory responses to the electrospun mesh and promote functional tissue remodeling for clinical abdominal wall repair.<\/jats:p>","DOI":"10.1002\/jbm.a.70100","type":"journal-article","created":{"date-parts":[[2026,6,4]],"date-time":"2026-06-04T07:12:09Z","timestamp":1780557129000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["A Multifunctional Electrospun Membrane for Full\u2010Thickness Abdominal Wall Defect Repair"],"prefix":"10.1002","volume":"114","author":[{"given":"Qiaolin","family":"Ma","sequence":"first","affiliation":[{"name":"Shanghai Engineering Research Center of Nano\u2010Biomaterials and Regenerative Medicine, Department of Biomedical Engineering Donghua University  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiajie","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Hernia and Abdominal Wall Surgery Shanghai East Hospital, School of Medicine, Tongji University  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rui","family":"Tang","sequence":"additional","affiliation":[{"name":"Department of Hernia and Abdominal Wall Surgery Shanghai East Hospital, School of Medicine, Tongji University  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Beili","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of General Surgery Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7262-2568","authenticated-orcid":false,"given":"Zhengni","family":"Liu","sequence":"additional","affiliation":[{"name":"Australian Institute for Bioengineering and Nanotechnology, The University of Queensland  St Lucia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinglei","family":"Wu","sequence":"additional","affiliation":[{"name":"Shanghai Engineering Research Center of Nano\u2010Biomaterials and Regenerative Medicine, Department of Biomedical Engineering Donghua University  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,6,4]]},"reference":[{"issue":"6","key":"e_1_2_10_2_1","doi-asserted-by":"crossref","first-page":"2064","DOI":"10.1021\/acsbiomaterials.1c00118","article-title":"Functionalized Strategies and Mechanisms of the Emerging Mesh for Abdominal Wall Repair and 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Inflammation and the Foreign Body Response to Orthopedic Biomaterials","volume":"112","author":"Gibon E.","year":"2023","journal-title":"Journal of Biomedical Materials Research, Part A"},{"issue":"6","key":"e_1_2_10_43_1","doi-asserted-by":"crossref","first-page":"822","DOI":"10.3390\/polym17060822","article-title":"Extracellular Matrix Stiffness: Mechanotransduction and Mechanobiological Response\u2010Driven Strategies for Biomedical Applications Targeting Fibroblast Inflammation","volume":"17","author":"Tiskratok W.","year":"2025","journal-title":"Polymers"},{"issue":"5","key":"e_1_2_10_44_1","doi-asserted-by":"crossref","first-page":"661","DOI":"10.1007\/s13770-023-00536-x","article-title":"Development of Matrix Metalloproteinases\u2010Mediated Extracellular Matrix Remodeling in Regenerative Medicine: A Mini Review","volume":"20","author":"Chen K.","year":"2023","journal-title":"Tissue Engineering and Regenerative Medicine"},{"issue":"10","key":"e_1_2_10_45_1","first-page":"2477","article-title":"Role of Matrix Metalloproteinases in Musculoskeletal Diseases","volume":"10","author":"Kumar L.","year":"2022","journal-title":"Biomedicine"},{"issue":"4","key":"e_1_2_10_46_1","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1002\/jor.21009","article-title":"Ibuprofen Upregulates Expressions of Matrix Metalloproteinase\u20101, \u22128, \u22129, and \u221213 Without Affecting Expressions of Types I and III Collagen in Tendon Cells","volume":"28","author":"Tsai W.\u2010C.","year":"2010","journal-title":"Journal of Orthopaedic Research"}],"container-title":["Journal of Biomedical Materials Research Part A"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jbm.a.70100","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/jbm.a.70100","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jbm.a.70100","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,6,4]],"date-time":"2026-06-04T07:12:15Z","timestamp":1780557135000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jbm.a.70100"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,6]]},"references-count":45,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2026,6]]}},"alternative-id":["10.1002\/jbm.a.70100"],"URL":"https:\/\/doi.org\/10.1002\/jbm.a.70100","archive":["Portico"],"relation":{},"ISSN":["1549-3296","1552-4965"],"issn-type":[{"value":"1549-3296","type":"print"},{"value":"1552-4965","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,6]]},"assertion":[{"value":"2026-04-07","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-05-20","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-06-04","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70100"}}