{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,4]],"date-time":"2026-06-04T08:08:08Z","timestamp":1780560488408,"version":"3.54.1"},"reference-count":87,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2026,6,4]],"date-time":"2026-06-04T00:00:00Z","timestamp":1780531200000},"content-version":"vor","delay-in-days":3,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100020410","name":"T\u00fcrkiye Sa\u011fl\u0131k Enstit\u00fcleri Ba\u015fkanl\u0131\u011f\u0131","doi-asserted-by":"publisher","award":["33815"],"award-info":[{"award-number":["33815"]}],"id":[{"id":"10.13039\/100020410","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Biomedical Materials Res"],"published-print":{"date-parts":[[2026,6]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Chronic diabetic wounds remain a major clinical challenge because of persistent inflammation, excessive oxidative stress, impaired angiogenesis, and high susceptibility to infection. This study aims to develop a multifunctional hydrogel system composed of gelatin methacryloyl (GelMA; 7.5%, 10%, 15%), chitosan (2%), zeolite (1%), and glutathione (0.15\u2009mg\/mL) that can concurrently deliver antioxidant therapy, prevent infection, and support tissue regeneration in diabetic wounds. All GelMA\/chitosan\/zeolite\/glutathione (Gel\u2010CZG) hydrogels exhibited solid\u2010like viscoelastic behavior and shear\u2010thinning properties, with increasing GelMA concentration yielding higher stiffness. FTIR analysis confirmed the successful incorporation of glutathione, chitosan, and zeolite. SEM imaging revealed a highly interconnected porous microstructure, with pore size decreasing as GelMA concentration increased. Sustained glutathione release was achieved for up to 21\u2009days, following a diffusion\u2010controlled mechanism. The hydrogels were cytocompatible, supported fibroblast adhesion and proliferation, and modulated key inflammatory (e.g., IL\u20101\u03b2, TNF\u2010\u03b1, IL\u20106, MMP13) and regenerative (e.g., IGF1, COL1A1) genes in a concentration\u2010dependent manner. All formulations demonstrated &gt;\u200990% antibacterial activity against\n                    <jats:styled-content style=\"fixed-case\">\n                      <jats:italic>E. coli<\/jats:italic>\n                    <\/jats:styled-content>\n                    ,\n                    <jats:styled-content style=\"fixed-case\">\n                      <jats:italic>S. aureus<\/jats:italic>\n                    <\/jats:styled-content>\n                    , and\n                    <jats:styled-content style=\"fixed-case\">\n                      <jats:italic>P. aeruginosa<\/jats:italic>\n                    <\/jats:styled-content>\n                    and inhibited\n                    <jats:styled-content style=\"fixed-case\">\n                      <jats:italic>P. aeruginosa<\/jats:italic>\n                    <\/jats:styled-content>\n                    biofilm formation by \u2265\u200995%. Overall, the designed Gel\u2010CZG hydrogels provide a robust and tunable platform that integrates sustained glutathione delivery, antibacterial action, and regenerative support.\n                  <\/jats:p>","DOI":"10.1002\/jbm.a.70101","type":"journal-article","created":{"date-parts":[[2026,6,4]],"date-time":"2026-06-04T07:38:58Z","timestamp":1780558738000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Controlled Glutathione\u2010Releasing Multifunctional Gelatin Methacryloyl\/Chitosan\/Zeolite Hydrogels for Accelerated Regeneration in Diabetic Wounds"],"prefix":"10.1002","volume":"114","author":[{"given":"Fatma Betul","family":"Kabadas","sequence":"first","affiliation":[{"name":"Istanbul Faculty of Medicine Istanbul University  Istanbul T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tuba","family":"Bedir","sequence":"additional","affiliation":[{"name":"Nanotechnology and Biomaterials Research Group, Department of Metallurgical and Materials Engineering, Faculty of Technology Marmara University  Istanbul T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elif","family":"Ilhan","sequence":"additional","affiliation":[{"name":"Nanotechnology and Biomaterials Research Group, Department of Metallurgical and Materials Engineering, Faculty of Technology Marmara University  Istanbul T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zehra","family":"Kanli","sequence":"additional","affiliation":[{"name":"Nanotechnology and Biomaterials Research Group, Department of Metallurgical and Materials Engineering, Faculty of Technology Marmara University  Istanbul T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Banu","family":"Aydin","sequence":"additional","affiliation":[{"name":"Department of Biophysics, School of Medicine Marmara University  Istanbul T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elif","family":"Kaya","sequence":"additional","affiliation":[{"name":"Department of Biochemistry, Faculty of Pharmacy, Institute of Health Sciences Marmara University  Istanbul T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gulgun Bosgelmez","family":"Tinaz","sequence":"additional","affiliation":[{"name":"Department of Basic Pharmaceutical Sciences, Faculty of Pharmacy Marmara University  Istanbul T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-7052-798X","authenticated-orcid":false,"given":"Okan Mustafa","family":"Gursoy","sequence":"additional","affiliation":[{"name":"Istanbul Faculty of Medicine Istanbul University  Istanbul T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4926-6489","authenticated-orcid":false,"given":"Oguzhan","family":"Gunduz","sequence":"additional","affiliation":[{"name":"Nanotechnology and Biomaterials Research Group, Department of Metallurgical and Materials Engineering, Faculty of Technology Marmara University  Istanbul T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roger","family":"Narayan","sequence":"additional","affiliation":[{"name":"Joint Department of Biomedical Engineering North Carolina State University  Raleigh North Carolina USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,6,4]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"crossref","first-page":"560","DOI":"10.1089\/wound.2015.0635","article-title":"Challenges in the Treatment of the Chronic Wounds","volume":"4","author":"Frykberg R. 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