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In this study, we report the novel development of a multifunctional chitosan\/collagen (CS\/Coll) hydrogel integrated with praseodymium\u2010doped mesoporous bioactive glass nanoparticles (Pr\u2010MBGNs) engineered for the first time to simultaneously scavenge reactive oxygen species (ROS) and promote osteogenesis. The antioxidant potential of the Pr\u2010MBGNs\u2010loaded hydrogels was confirmed through hydrogen peroxide (H\n                    <jats:sub>2<\/jats:sub>\n                    O\n                    <jats:sub>2<\/jats:sub>\n                    ) scavenging assays, demonstrating over 98% H\n                    <jats:sub>2<\/jats:sub>\n                    O\n                    <jats:sub>2<\/jats:sub>\n                    reduction at optimal concentrations with significant reduction in intracellular ROS production. Under oxidative stress conditions, the hydrogels significantly restored rMSC viability, enhanced cell adhesion, and supported sustained proliferation. Mechanically, the incorporation of Pr\u2010MBGNs modulated hydrogel crosslink density and stiffness, which favor improved cell\u2013material interactions. Osteogenic assays showed a significant upregulation of key osteogenic markers (RUNX2, OCN, and OSX) and increase in matrix mineralization over 28\u2009days. These outcomes are attributed to the synergistic effect of antioxidant protection and sustained release of bioactive ions from the Pr\u2010MBGNs, which reprogrammed the redox environment and enhanced the osteoinductive microenvironment. Collectively, this study presents a first\u2010of\u2010its\u2010kind nanoengineered hydrogel system that integrates ROS scavenging and osteogenic stimulation, offering a promising biomimetic strategy for bone tissue engineering in oxidative stress\u2010related pathological conditions.\n                  <\/jats:p>","DOI":"10.1002\/jbm.a.70128","type":"journal-article","created":{"date-parts":[[2026,9,4]],"date-time":"2026-09-04T11:06:59Z","timestamp":1788520019000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Antioxidant\u2010Thermoresponsive Collagen\/Chitosan Nanocomposite Hydrogels With Praseodymium\u2010Doped Mesoporous Bioglass for Enhanced Bone Regeneration"],"prefix":"10.1002","volume":"114","author":[{"given":"Kulwinder","family":"Kaur","sequence":"first","affiliation":[{"name":"School of Pharmacy &amp; Biomolecular Sciences Royal College of Surgeons in Ireland (RCSI)  Dublin Ireland"},{"name":"Tissue Engineering Research Group, Department of Anatomy &amp; Regenerative Medicine Royal College of Surgeons in Ireland (RCSI)  Dublin Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhiyan","family":"Xu","sequence":"additional","affiliation":[{"name":"Institute of Biomaterials, University of Erlangen\u2010Nuremberg  Erlangen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7377-2955","authenticated-orcid":false,"given":"Aldo. 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