{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T08:02:38Z","timestamp":1789459358184,"version":"build-2803163510"},"reference-count":210,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2026,9,4]],"date-time":"2026-09-04T00:00:00Z","timestamp":1788480000000},"content-version":"vor","delay-in-days":3,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100018542","name":"Natural Science Foundation of Sichuan Province","doi-asserted-by":"publisher","award":["2024NSFSC0603"],"award-info":[{"award-number":["2024NSFSC0603"]}],"id":[{"id":"10.13039\/501100018542","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Biomedical Materials Res"],"published-print":{"date-parts":[[2026,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Graphene\u2010based nanomaterials (GBNs), such as graphene oxide and reduced graphene oxide, have been considered as promising functional materials for bone tissue engineering due largely to their intrinsic biological functions and great drug delivery capacity. As bioactive materials, GBNs possess antibacterial activity, photothermal effect, and the ability to regulate immune microenvironment and osteogenesis\u2010related signaling pathways such as Wnt\/\u03b2\u2010catenin, MAPK, and BMP\/Smad. As drug delivery systems, the large surface area and multiple functionalization sites allow GBNs to have great potential in loading and delivering various active agents, such as drugs, genes, and growth factors. Based on these properties, GBNs prevent infections, facilitate stem cell adhesion, proliferation, and osteogenic differentiation, and ultimately promote bone regeneration. In the past few years, reports regarding the applications of GBNs in bone tissue engineering have been well documented, but the clinical translation is still limited. Herein, on the basis of the two major roles of GBNs (bioactive agents and drug delivery systems), we aim to provide a comprehensive understanding of the multiple functions and mechanisms of GBNs in promoting bone tissue regeneration. The progress and challenges in clinical translation are also discussed.<\/jats:p>","DOI":"10.1002\/jbm.a.70129","type":"journal-article","created":{"date-parts":[[2026,9,5]],"date-time":"2026-09-05T05:47:11Z","timestamp":1788587231000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Graphene\u2010Based Nanomaterials as Bioactive Agents and Drug Delivery Systems for Bone Tissue Engineering"],"prefix":"10.1002","volume":"114","author":[{"given":"Sijian","family":"Yu","sequence":"first","affiliation":[{"name":"State Key Laboratory of Oral Diseases and National Center for Stomatology and National Clinical Research Center for Oral Diseases, West China Hospital of Stomatology Sichuan University  Chengdu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianhong","family":"Liu","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Oral Diseases and National Center for Stomatology and National Clinical Research Center for Oral Diseases, West China Hospital of Stomatology Sichuan University  Chengdu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xueer","family":"Zhou","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Oral Diseases and National Center for Stomatology and National Clinical Research Center for Oral Diseases, West China Hospital of Stomatology Sichuan University  Chengdu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2268-3178","authenticated-orcid":false,"given":"Qiang","family":"Peng","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Oral Diseases and National Center for Stomatology and National Clinical Research Center for Oral Diseases, West China Hospital of Stomatology Sichuan University  Chengdu China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,9,4]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bcp.2020.114308"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.injury.2021.01.016"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.2147\/IJN.S442768"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.3390\/bioengineering12121336"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12938-023-01067-1"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms24010529"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.2147\/IJN.S416098"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12938\u2010025\u201001342\u20103"},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.3390\/ph15081023"},{"key":"e_1_2_12_11_1","doi-asserted-by":"publisher","DOI":"10.1088\/1758\u20105090\/adbcdd"},{"key":"e_1_2_12_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bone.2024.117363"},{"key":"e_1_2_12_13_1","doi-asserted-by":"publisher","DOI":"10.3390\/pharmaceutics16020204"},{"key":"e_1_2_12_14_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40204\u2010022\u201000185\u20108"},{"key":"e_1_2_12_15_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13346\u2010015\u20100236\u20100"},{"key":"e_1_2_12_16_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsami.2c02001"},{"key":"e_1_2_12_17_1","doi-asserted-by":"publisher","DOI":"10.7507\/1002\u20101892.202410011"},{"key":"e_1_2_12_18_1","doi-asserted-by":"publisher","DOI":"10.3390\/nano9040590"},{"key":"e_1_2_12_19_1","doi-asserted-by":"publisher","DOI":"10.1002\/advs.202205292"},{"key":"e_1_2_12_20_1","doi-asserted-by":"publisher","DOI":"10.2147\/ijn.S464025"},{"key":"e_1_2_12_21_1","doi-asserted-by":"publisher","DOI":"10.3389\/fbioe.2020.621788"},{"key":"e_1_2_12_22_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsbiomedchemau.4c00152"},{"key":"e_1_2_12_23_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13287\u2010021\u201002634\u2010w"},{"key":"e_1_2_12_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.scib.2019.09.021"},{"key":"e_1_2_12_25_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12951\u2010025\u201003622\u20105"},{"key":"e_1_2_12_26_1","doi-asserted-by":"publisher","DOI":"10.1039\/D0CS01541E"},{"key":"e_1_2_12_27_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11837-022-05505-8"},{"key":"e_1_2_12_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cis.2024.103357"},{"key":"e_1_2_12_29_1","doi-asserted-by":"publisher","DOI":"10.3390\/nano13192666"},{"key":"e_1_2_12_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.colsurfa.2026.139550"},{"key":"e_1_2_12_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejmech.2024.116508"},{"key":"e_1_2_12_32_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsbiomaterials.2c00396"},{"key":"e_1_2_12_33_1","doi-asserted-by":"publisher","DOI":"10.3390\/pharmaceutics14091834"},{"key":"e_1_2_12_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcis.2023.08.126"},{"key":"e_1_2_12_35_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12274\u2010020\u20103064\u20106"},{"key":"e_1_2_12_36_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00449\u2010022\u201002717\u20109"},{"key":"e_1_2_12_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.colsurfb.2020.111502"},{"key":"e_1_2_12_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2024.118141"},{"key":"e_1_2_12_39_1","doi-asserted-by":"publisher","DOI":"10.1186\/s11671-024-04032-6"},{"key":"e_1_2_12_40_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.chemosphere.2022.136934"},{"key":"e_1_2_12_41_1","doi-asserted-by":"publisher","DOI":"10.1080\/10408347.2022.2025758"},{"key":"e_1_2_12_42_1","doi-asserted-by":"publisher","DOI":"10.1002\/adhm.202201523"},{"key":"e_1_2_12_43_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsami.4c10284"},{"key":"e_1_2_12_44_1","doi-asserted-by":"publisher","DOI":"10.3389\/fchem.2023.1213507"},{"key":"e_1_2_12_45_1","doi-asserted-by":"publisher","DOI":"10.1002\/adhm.202001414"},{"key":"e_1_2_12_46_1","doi-asserted-by":"publisher","DOI":"10.1039\/c1cs15078b"},{"key":"e_1_2_12_47_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.compscitech.2012.05.005"},{"key":"e_1_2_12_48_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10924\u2010019\u201001613\u2010w"},{"key":"e_1_2_12_49_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijbiomac.2025.145488"},{"key":"e_1_2_12_50_1","doi-asserted-by":"publisher","DOI":"10.1038\/srep46604"},{"key":"e_1_2_12_51_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598\u2010024\u201080467\u20102"},{"key":"e_1_2_12_52_1","doi-asserted-by":"publisher","DOI":"10.1063\/5.0223785"},{"key":"e_1_2_12_53_1","doi-asserted-by":"publisher","DOI":"10.3390\/polym16010129"},{"key":"e_1_2_12_54_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.msec.2020.111588"},{"key":"e_1_2_12_55_1","doi-asserted-by":"publisher","DOI":"10.2147\/IJN.S204971"},{"key":"e_1_2_12_56_1","doi-asserted-by":"publisher","DOI":"10.1002\/adhm.202501941"},{"key":"e_1_2_12_57_1","doi-asserted-by":"publisher","DOI":"10.1002\/smsc.202400414"},{"key":"e_1_2_12_58_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.msec.2019.03.047"},{"key":"e_1_2_12_59_1","doi-asserted-by":"publisher","DOI":"10.1002\/advs.202404190"},{"key":"e_1_2_12_60_1","doi-asserted-by":"publisher","DOI":"10.1002\/adma.201200011"},{"key":"e_1_2_12_61_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.carbon.2024.119055"},{"key":"e_1_2_12_62_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsnano.3c12274"},{"key":"e_1_2_12_63_1","doi-asserted-by":"publisher","DOI":"10.1021\/nl200758b"},{"key":"e_1_2_12_64_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mattod.2023.06.011"},{"key":"e_1_2_12_65_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.msec.2019.110312"},{"key":"e_1_2_12_66_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.matdes.2021.109473"},{"key":"e_1_2_12_67_1","doi-asserted-by":"publisher","DOI":"10.1002\/adhm.202404490"},{"key":"e_1_2_12_68_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms24119375"},{"key":"e_1_2_12_69_1","doi-asserted-by":"publisher","DOI":"10.3390\/pharmaceutics15041116"},{"key":"e_1_2_12_70_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsami.3c09860"},{"key":"e_1_2_12_71_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bioadv.2024.213820"},{"key":"e_1_2_12_72_1","doi-asserted-by":"publisher","DOI":"10.1166\/jbn.2022.3236"},{"key":"e_1_2_12_73_1","doi-asserted-by":"publisher","DOI":"10.1080\/02652048.2016.1267811"},{"key":"e_1_2_12_74_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cej.2020.127413"},{"key":"e_1_2_12_75_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jconrel.2019.06.011"},{"key":"e_1_2_12_76_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bioadv.2024.214080"},{"key":"e_1_2_12_77_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41579\u2010022\u201000686\u20100"},{"key":"e_1_2_12_78_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41572\u2010022\u201000396\u20100"},{"key":"e_1_2_12_79_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.carbon.2023.118740"},{"key":"e_1_2_12_80_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10853\u2010023\u201008534\u2010z"},{"key":"e_1_2_12_81_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.isci.2020.101787"},{"key":"e_1_2_12_82_1","doi-asserted-by":"publisher","DOI":"10.1039\/D0RA07945F"},{"key":"e_1_2_12_83_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.colsurfb.2020.111009"},{"key":"e_1_2_12_84_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsnano.5b02067"},{"key":"e_1_2_12_85_1","doi-asserted-by":"publisher","DOI":"10.3390\/biom13111571"},{"key":"e_1_2_12_86_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.dental.2024.10.009"},{"key":"e_1_2_12_87_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12917\u2010022\u201003560\u20106"},{"key":"e_1_2_12_88_1","doi-asserted-by":"publisher","DOI":"10.1002\/tcr.202000090"},{"key":"e_1_2_12_89_1","doi-asserted-by":"publisher","DOI":"10.3791\/66762"},{"key":"e_1_2_12_90_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbiosy.2022.100069"},{"key":"e_1_2_12_91_1","doi-asserted-by":"publisher","DOI":"10.1038\/nnano.2013.125"},{"key":"e_1_2_12_92_1","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.5b11411"},{"key":"e_1_2_12_93_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsnano.9b04970"},{"key":"e_1_2_12_94_1","doi-asserted-by":"publisher","DOI":"10.1111\/cpr.12367"},{"key":"e_1_2_12_95_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms24032691"},{"key":"e_1_2_12_96_1","doi-asserted-by":"publisher","DOI":"10.1002\/smll.201201417"},{"key":"e_1_2_12_97_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsnano.8b04758"},{"key":"e_1_2_12_98_1","doi-asserted-by":"publisher","DOI":"10.3390\/nano9020139"},{"key":"e_1_2_12_99_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41699\u2010022\u201000330\u20108"},{"key":"e_1_2_12_100_1","doi-asserted-by":"publisher","DOI":"10.3390\/biomimetics9110651"},{"key":"e_1_2_12_101_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13018\u2010024\u201005028\u20109"},{"key":"e_1_2_12_102_1","doi-asserted-by":"publisher","DOI":"10.1002\/smll.202301201"},{"key":"e_1_2_12_103_1","doi-asserted-by":"publisher","DOI":"10.1039\/C9EN00355J"},{"key":"e_1_2_12_104_1","doi-asserted-by":"publisher","DOI":"10.3390\/ph17020170"},{"key":"e_1_2_12_105_1","doi-asserted-by":"publisher","DOI":"10.1002\/term.3239"},{"key":"e_1_2_12_106_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijbiomac.2023.125593"},{"key":"e_1_2_12_107_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.msec.2021.112587"},{"key":"e_1_2_12_108_1","doi-asserted-by":"publisher","DOI":"10.1088\/1748\u2010605X\/ac6eab"},{"key":"e_1_2_12_109_1","doi-asserted-by":"publisher","DOI":"10.1002\/term.2119"},{"key":"e_1_2_12_110_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhazmat.2022.129954"},{"key":"e_1_2_12_111_1","doi-asserted-by":"publisher","DOI":"10.1021\/nn101097v"},{"key":"e_1_2_12_112_1","unstructured":"H. C.Bidsorkhi E.Bruni L. R.Ballam et\u00a0al. \u201cGraphene\u2010Based Antibacterial Coatings for Dental Applications \u201dinNanoinnovation (2021)."},{"key":"e_1_2_12_113_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhazmat.2021.125333"},{"key":"e_1_2_12_114_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jconrel.2019.02.015"},{"key":"e_1_2_12_115_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12951\u2010021\u201000831\u20106"},{"key":"e_1_2_12_116_1","doi-asserted-by":"publisher","DOI":"10.1039\/C5RA05393E"},{"key":"e_1_2_12_117_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcis.2023.01.079"},{"key":"e_1_2_12_118_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.matchemphys.2025.131299"},{"key":"e_1_2_12_119_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.apsusc.2025.162942"},{"key":"e_1_2_12_120_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.drudis.2021.03.002"},{"key":"e_1_2_12_121_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms25137182"},{"key":"e_1_2_12_122_1","doi-asserted-by":"publisher","DOI":"10.1039\/D4BM00796D"},{"key":"e_1_2_12_123_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.envpol.2019.01.072"},{"key":"e_1_2_12_124_1","doi-asserted-by":"publisher","DOI":"10.1039\/c8sc02100g"},{"key":"e_1_2_12_125_1","doi-asserted-by":"publisher","DOI":"10.34172\/bi.30835"},{"key":"e_1_2_12_126_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsabm.3c00400"},{"key":"e_1_2_12_127_1","doi-asserted-by":"publisher","DOI":"10.2147\/IJN.S380345"},{"key":"e_1_2_12_128_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsbiomaterials.9b00497"},{"key":"e_1_2_12_129_1","doi-asserted-by":"publisher","DOI":"10.1021\/nn202190c"},{"key":"e_1_2_12_130_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jconrel.2025.114393"},{"key":"e_1_2_12_131_1","doi-asserted-by":"publisher","DOI":"10.1002\/jbm.a.36791"},{"key":"e_1_2_12_132_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsami.8b22606"},{"key":"e_1_2_12_133_1","doi-asserted-by":"publisher","DOI":"10.2147\/IJN.S115468"},{"key":"e_1_2_12_134_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12951\u2010021\u201001024\u2010x"},{"key":"e_1_2_12_135_1","doi-asserted-by":"publisher","DOI":"10.1080\/21691401.2019.1576706"},{"key":"e_1_2_12_136_1","doi-asserted-by":"publisher","DOI":"10.2147\/IJN.S105794"},{"key":"e_1_2_12_137_1","doi-asserted-by":"publisher","DOI":"10.2174\/1389450120666190821161259"},{"key":"e_1_2_12_138_1","doi-asserted-by":"publisher","DOI":"10.2174\/0113892010289575240306033011"},{"key":"e_1_2_12_139_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.intimp.2024.113380"},{"key":"e_1_2_12_140_1","doi-asserted-by":"publisher","DOI":"10.1039\/c8bm00127h"},{"key":"e_1_2_12_141_1","doi-asserted-by":"publisher","DOI":"10.3389\/fbioe.2023.1129768"},{"key":"e_1_2_12_142_1","doi-asserted-by":"publisher","DOI":"10.1186\/s40824\u2010022\u201000313\u20102"},{"key":"e_1_2_12_143_1","doi-asserted-by":"publisher","DOI":"10.1097\/CM9.0000000000003680"},{"key":"e_1_2_12_144_1","doi-asserted-by":"publisher","DOI":"10.1080\/09205063.2021.1937464"},{"key":"e_1_2_12_145_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.msec.2019.109946"},{"key":"e_1_2_12_146_1","doi-asserted-by":"publisher","DOI":"10.1002\/adfm.202423821"},{"key":"e_1_2_12_147_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsami.6b02032"},{"key":"e_1_2_12_148_1","doi-asserted-by":"publisher","DOI":"10.1007\/s42247\u2010024\u201000804\u2010z"},{"key":"e_1_2_12_149_1","doi-asserted-by":"publisher","DOI":"10.3390\/polym13162628"},{"key":"e_1_2_12_150_1","doi-asserted-by":"publisher","DOI":"10.1080\/23312009.2020.1833476"},{"key":"e_1_2_12_151_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.drudis.2017.04.002"},{"key":"e_1_2_12_152_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mtcomm.2022.104108"},{"key":"e_1_2_12_153_1","doi-asserted-by":"publisher","DOI":"10.1021\/am401523y"},{"key":"e_1_2_12_154_1","doi-asserted-by":"publisher","DOI":"10.1039\/c1jm10341e"},{"key":"e_1_2_12_155_1","doi-asserted-by":"publisher","DOI":"10.1002\/advs.201700578"},{"key":"e_1_2_12_156_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsbiomaterials.4c00774"},{"key":"e_1_2_12_157_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms24065799"},{"key":"e_1_2_12_158_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10856\u2010020\u201006430\u20105"},{"key":"e_1_2_12_159_1","doi-asserted-by":"publisher","DOI":"10.1039\/c8ra05250f"},{"key":"e_1_2_12_160_1","doi-asserted-by":"publisher","DOI":"10.1002\/jbm.a.36974"},{"key":"e_1_2_12_161_1","doi-asserted-by":"publisher","DOI":"10.2147\/IJN.S82354"},{"key":"e_1_2_12_162_1","doi-asserted-by":"publisher","DOI":"10.1039\/d4tb02330g"},{"key":"e_1_2_12_163_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsami.3c05297"},{"key":"e_1_2_12_164_1","doi-asserted-by":"publisher","DOI":"10.1039\/d4tb02553a"},{"key":"e_1_2_12_165_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jmbbm.2023.106263"},{"key":"e_1_2_12_166_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsbiomaterials.0c00613"},{"key":"e_1_2_12_167_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10856\u2010025\u201006905\u20103"},{"key":"e_1_2_12_168_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.colsurfb.2021.112102"},{"key":"e_1_2_12_169_1","doi-asserted-by":"publisher","DOI":"10.2147\/ijn.S467886"},{"key":"e_1_2_12_170_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12967\u2010024\u201005020\u20101"},{"key":"e_1_2_12_171_1","doi-asserted-by":"publisher","DOI":"10.1002\/adhm.202501376"},{"key":"e_1_2_12_172_1","doi-asserted-by":"publisher","DOI":"10.1002\/jbm.a.37829"},{"key":"e_1_2_12_173_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.actbio.2022.09.019"},{"key":"e_1_2_12_174_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsabm.5c01784"},{"key":"e_1_2_12_175_1","doi-asserted-by":"publisher","DOI":"10.1002\/term.3297"},{"key":"e_1_2_12_176_1","doi-asserted-by":"publisher","DOI":"10.1093\/ageing\/afl081"},{"key":"e_1_2_12_177_1","doi-asserted-by":"publisher","DOI":"10.2215\/CJN.04151206"},{"key":"e_1_2_12_178_1","doi-asserted-by":"publisher","DOI":"10.1186\/1749-799X-9-18"},{"key":"e_1_2_12_179_1","doi-asserted-by":"publisher","DOI":"10.1002\/adfm.202010609"},{"key":"e_1_2_12_180_1","doi-asserted-by":"publisher","DOI":"10.2147\/IJN.S164869"},{"key":"e_1_2_12_181_1","doi-asserted-by":"publisher","DOI":"10.1016\/S8756-3282(02)00735-4"},{"key":"e_1_2_12_182_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.matdes.2021.109865"},{"key":"e_1_2_12_183_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2005.10.003"},{"key":"e_1_2_12_184_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.actbio.2016.09.005"},{"key":"e_1_2_12_185_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1527\u20102648(199909)1:1<11::AID\u2010ADEM11>3.0.CO;2\u2010N"},{"key":"e_1_2_12_186_1","doi-asserted-by":"publisher","DOI":"10.1089\/ten.TEB.2011.0475"},{"key":"e_1_2_12_187_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.drudis.2014.04.010"},{"key":"e_1_2_12_188_1","doi-asserted-by":"publisher","DOI":"10.3390\/nano7110369"},{"key":"e_1_2_12_189_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600\u20100757.2000.2220102.x"},{"key":"e_1_2_12_190_1","doi-asserted-by":"publisher","DOI":"10.1186\/1742-4933-10-23"},{"key":"e_1_2_12_191_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.intimp.2025.114683"},{"key":"e_1_2_12_192_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2024.119270"},{"key":"e_1_2_12_193_1","doi-asserted-by":"publisher","DOI":"10.1177\/0022034514552491"},{"key":"e_1_2_12_194_1","doi-asserted-by":"publisher","DOI":"10.1016\/s0140\u20106736(05)67728\u20108"},{"key":"e_1_2_12_195_1","doi-asserted-by":"publisher","DOI":"10.1111\/prd.12342"},{"key":"e_1_2_12_196_1","doi-asserted-by":"publisher","DOI":"10.1111\/prd.12201"},{"key":"e_1_2_12_197_1","doi-asserted-by":"publisher","DOI":"10.1111\/clr.13121"},{"key":"e_1_2_12_198_1","doi-asserted-by":"publisher","DOI":"10.1097\/ID.0b013e318031224a"},{"key":"e_1_2_12_199_1","doi-asserted-by":"publisher","DOI":"10.1002\/jbm.b.31711"},{"key":"e_1_2_12_200_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13018\u2010022\u201003122\u20104"},{"key":"e_1_2_12_201_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12903\u2010023\u201003026\u20107"},{"key":"e_1_2_12_202_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.actbio.2022.10.030"},{"key":"e_1_2_12_203_1","doi-asserted-by":"publisher","DOI":"10.1039\/d2tb01684b"},{"key":"e_1_2_12_204_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jbiomech.2005.03.028"},{"key":"e_1_2_12_205_1","doi-asserted-by":"publisher","DOI":"10.1111\/os.12264"},{"key":"e_1_2_12_206_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1470\u20102045(05)01734\u20101"},{"key":"e_1_2_12_207_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.molpharmaceut.3c00802"},{"key":"e_1_2_12_208_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11051\u2010014\u20102822\u20103"},{"key":"e_1_2_12_209_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40843\u2010018\u20109293\u20108"},{"key":"e_1_2_12_210_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jbiosc.2024.07.018"},{"key":"e_1_2_12_211_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jconrel.2025.114494"}],"container-title":["Journal of Biomedical Materials Research Part A"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jbm.a.70129","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/jbm.a.70129","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jbm.a.70129","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T07:07:40Z","timestamp":1789456060000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jbm.a.70129"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9]]},"references-count":210,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2026,9]]}},"alternative-id":["10.1002\/jbm.a.70129"],"URL":"https:\/\/doi.org\/10.1002\/jbm.a.70129","archive":["Portico"],"relation":{},"ISSN":["1549-3296","1552-4965"],"issn-type":[{"value":"1549-3296","type":"print"},{"value":"1552-4965","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,9]]},"assertion":[{"value":"2026-04-16","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-07-07","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-09-04","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70129"}}