{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,14]],"date-time":"2026-08-14T09:28:56Z","timestamp":1786699736630,"version":"build-2736575974"},"reference-count":46,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2026,8,5]],"date-time":"2026-08-05T00:00:00Z","timestamp":1785888000000},"content-version":"vor","delay-in-days":4,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82271123"],"award-info":[{"award-number":["82271123"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82371102"],"award-info":[{"award-number":["82371102"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012226","name":"Fundamental Research Funds for the Central Universities","doi-asserted-by":"publisher","award":["YG2025QNB15"],"award-info":[{"award-number":["YG2025QNB15"]}],"id":[{"id":"10.13039\/501100012226","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Biomedical Materials Res"],"published-print":{"date-parts":[[2026,8]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Magnesium\u2010based biomaterials show great potential in bone regeneration due to their inherent biocompatibility, osteogenic activity, and ability to modulate the immune microenvironment. However, their rapid degradation rate remains a critical barrier to clinical translation. To address these challenges, we developed a magnesium hydride\u2010gelatin methacryloyl (MgH\n                    <jats:sub>2<\/jats:sub>\n                    \u2010GelMA) composite with sustained release of hydrogen gas and magnesium ions, featuring a bone\u2010mimetic organic\u2013inorganic hybrid network. First, magnesium hydride microcrystals were coated with an inorganic silica layer to mitigate degradation; subsequently, the coated particles were embedded within an organic GelMA hydrogel matrix. The composite achieves controlled co\u2010release of magnesium ions (Mg\n                    <jats:sup>2+<\/jats:sup>\n                    ) and hydrogen gas (H\n                    <jats:sub>2<\/jats:sub>\n                    ). The released Mg\n                    <jats:sup>2+<\/jats:sup>\n                    directly stimulates the differentiation of bone marrow mesenchymal stem cells (BMSCs) into osteoblasts, accelerating osteogenesis. Concurrently, Mg\n                    <jats:sup>2+<\/jats:sup>\n                    and H\n                    <jats:sub>2<\/jats:sub>\n                    synergistically induce polarization of bone marrow\u2010derived macrophages (BMDMs) toward an anti\u2010inflammatory phenotype. During the active inflammatory phase, this polarization modulates the immune microenvironment and establishes a pro\u2010regenerative local niche. This study not only elucidates a novel ion\u2010gas synergistic mechanism but also provides innovative insights and theoretical foundations for advancing artificial bone materials from passive biomimetic replacement to active regenerative modulation.\n                  <\/jats:p>","DOI":"10.1002\/jbm.a.70130","type":"journal-article","created":{"date-parts":[[2026,8,6]],"date-time":"2026-08-06T04:44:37Z","timestamp":1785991477000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Bioinspired Integrated\n                    <scp>\n                      MgH\n                      <sub>2<\/sub>\n                    <\/scp>\n                    Hydrogel Synergistically Modulates the Osteo\u2010Immune Microenvironment for Enhanced Bone Repair"],"prefix":"10.1002","volume":"114","author":[{"given":"Rui","family":"Huang","sequence":"first","affiliation":[{"name":"State Key Laboratory of Eye Health, Department of Ophthalmology, Shanghai Ninth People's Hospital Shanghai Jiao Tong University School of Medicine, Shanghai Key Laboratory of Orbital Diseases and Ocular Oncology  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhonghua","family":"Yang","sequence":"additional","affiliation":[{"name":"National Engineering Research Center of Light Alloy Net Forming &amp; State, Key Laboratory of Metal Matrix Composite &amp; Center of Hydrogen Science School of Materials Science &amp; Engineering Shanghai Jiao Tong University  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miao","family":"Wang","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Eye Health, Department of Ophthalmology, Shanghai Ninth People's Hospital Shanghai Jiao Tong University School of Medicine, Shanghai Key Laboratory of Orbital Diseases and Ocular Oncology  Shanghai China"},{"name":"The First Affiliated Hospital of Bengbu Medical College  Bengbu 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People's Hospital Shanghai Jiao Tong University School of Medicine, Shanghai Key Laboratory of Orbital Diseases and Ocular Oncology  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenjiang","family":"Ding","sequence":"additional","affiliation":[{"name":"The First Affiliated Hospital of Bengbu Medical College  Bengbu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ping","family":"Gu","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Eye Health, Department of Ophthalmology, Shanghai Ninth People's Hospital Shanghai Jiao Tong University School of Medicine, Shanghai Key Laboratory of Orbital Diseases and Ocular Oncology  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ni","family":"Ni","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Eye Health, Department of Ophthalmology, Shanghai Ninth People's Hospital Shanghai Jiao Tong University School of Medicine, Shanghai Key Laboratory of Orbital Diseases and Ocular Oncology  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jia","family":"Pei","sequence":"additional","affiliation":[{"name":"National Engineering Research Center of Light Alloy Net Forming &amp; State, Key Laboratory of Metal Matrix Composite &amp; Center of Hydrogen Science School of Materials Science &amp; Engineering Shanghai Jiao Tong University  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9394-3969","authenticated-orcid":false,"given":"Xianqun","family":"Fan","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Eye Health, Department of Ophthalmology, Shanghai Ninth People's Hospital Shanghai Jiao Tong University School of Medicine, Shanghai Key Laboratory of Orbital Diseases and Ocular Oncology  Shanghai 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