{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,14]],"date-time":"2026-08-14T09:29:00Z","timestamp":1786699740651,"version":"build-2736575974"},"reference-count":38,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2026,8,5]],"date-time":"2026-08-05T00:00:00Z","timestamp":1785888000000},"content-version":"vor","delay-in-days":4,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100000069","name":"National Institute of Arthritis and Musculoskeletal and Skin Diseases","doi-asserted-by":"publisher","award":["R01 AR066361\u201006"],"award-info":[{"award-number":["R01 AR066361\u201006"]}],"id":[{"id":"10.13039\/100000069","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Biomedical Materials Res"],"published-print":{"date-parts":[[2026,8]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    This study presents a novel approach to enhance the early\u2010stage osseointegration of orthopedic implants through surface engineering. Lithium (Li), strontium (Sr), and silver (Ag)\u2010doped hydroxyapatite (HA) were coated on Ti6Al4V substrates using RF induction based plasma spray coating and loaded with polydopamine (PD) and\n                    <jats:styled-content style=\"fixed-case\">\n                      <jats:italic>Cissus quadrangularis<\/jats:italic>\n                    <\/jats:styled-content>\n                    extract (CQE). The engineered coating integrates bioactive metal ions, drug\u2010loaded polymer layers, and plant\u2010derived osteogenic compounds to accelerate bone healing. Co\u2010culture with mesenchymal stem cells and monocytes demonstrates that Li\u2010Sr\u2010Ag\u2010doped HA upregulated key osteogenic markers, including alkaline phosphatase and bone gamma\u2010carboxyglutamic acid\u2010containing protein, while also modulating osteoclastic activity. An in\u00a0vivo rat distal femur study demonstrated enhanced osteoid formation with the addition of CQE, promoting mineralized bone formation. We demonstrate that induction plasma spray can be used to design and manufacture doped HA coated implant with PD and CQE, thereby accelerating early stage osseointegration and providing a scalable, clinically translatable solution to enhance the performance of cementless orthopedic and dental implants.\n                  <\/jats:p>","DOI":"10.1002\/jbm.a.70135","type":"journal-article","created":{"date-parts":[[2026,8,6]],"date-time":"2026-08-06T04:56:47Z","timestamp":1785992207000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Design and Manufacturing of Multifunctional Hydroxyapatite\u2010Coated\n                    <scp>Ti6Al4V<\/scp>\n                    Implants With\n                    <scp>\n                      <i>Cissus quadrangularis<\/i>\n                    <\/scp>"],"prefix":"10.1002","volume":"114","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8601-016X","authenticated-orcid":false,"given":"Susmita","family":"Bose","sequence":"first","affiliation":[{"name":"W. 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