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This study presents an enzyme\u2010responsive nanoparticle\u2010based coating designed to enable localized and on\u2010demand antibiotic delivery on titanium implant surfaces. Hyaluronidase\u2010sensitive ciprofloxacin\u2010loaded mesoporous silica nanoparticles (MSNs) coated with hyaluronic acid (MSN\u2013CIP\u2013HA) were synthesized and deposited onto titanium substrates via electrophoretic deposition (EPD). The nanoparticles and coated surfaces were characterized in terms of morphology, surface properties, and wettability. Drug release behavior was evaluated under physiological (pH\u20097.4) and infection\u2010mimicking acidic (pH\u20095) conditions in the presence and absence of hyaluronidase. After 72\u2009h, ciprofloxacin release from coated titanium reached 0.51\u2009\u03bcg at pH\u20097.4 without enzyme and increased to 2.63\u2009\u03bcg in the presence of hyaluronidase. Similarly, release at pH\u20095 increased from 0.93 to 3.31\u2009\u03bcg following enzyme addition, indicating effective enzyme\u2010triggered degradation of the HA coating layer. Antibacterial performance against\n                    <jats:styled-content style=\"fixed-case\">\n                      <jats:italic>Escherichia coli<\/jats:italic>\n                    <\/jats:styled-content>\n                    and\n                    <jats:styled-content style=\"fixed-case\">\n                      <jats:italic>Staphylococcus aureus<\/jats:italic>\n                    <\/jats:styled-content>\n                    demonstrated reduced bacterial adhesion on coated surfaces and enhanced antibacterial efficacy under enzyme\u2010responsive conditions. The developed coating therefore combines anti\u2010adhesive surface properties with controlled, infection\u2010triggered antibiotic release, limiting unnecessary drug exposure while improving localized antibacterial activity. These findings highlight the potential of HA\u2010coated MSN coatings as smart implant surface modifications for reducing implant\u2010associated infections and biofilm formation.\n                  <\/jats:p>","DOI":"10.1002\/jbm.a.70138","type":"journal-article","created":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T12:39:10Z","timestamp":1785587950000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Hyaluronidase\u2010Responsive\n                    <scp>MSN<\/scp>\n                    \u2013\n                    <scp>HA<\/scp>\n                    Coatings for Infection\u2010Triggered Antibiotic Delivery on Titanium Surfaces"],"prefix":"10.1002","volume":"114","author":[{"given":"Merve","family":"Yolum","sequence":"first","affiliation":[{"name":"Department of Biomedical Engineering Yildiz Technical University  \u0130stanbul T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sakip","family":"\u00d6nder","sequence":"additional","affiliation":[{"name":"Department of Biomedical Engineering Yildiz Technical University  \u0130stanbul T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,8,1]]},"reference":[{"key":"e_1_2_11_2_1","volume-title":"Definitions in Biomaterials: Proceedings of a Consensus Conference of the European Society for Biomaterials, Chester, England, March 3\u20135, 1986","author":"Williams D. 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