{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,14]],"date-time":"2026-08-14T09:28:57Z","timestamp":1786699737373,"version":"build-2736575974"},"reference-count":40,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2026,8,11]],"date-time":"2026-08-11T00:00:00Z","timestamp":1786406400000},"content-version":"vor","delay-in-days":10,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100018552","name":"Science and Technology Plan Project of Taizhou","doi-asserted-by":"publisher","award":["25ywa30"],"award-info":[{"award-number":["25ywa30"]}],"id":[{"id":"10.13039\/501100018552","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100018552","name":"Science and Technology Plan Project of Taizhou","doi-asserted-by":"publisher","award":["23ywb124"],"award-info":[{"award-number":["23ywb124"]}],"id":[{"id":"10.13039\/501100018552","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Biomedical Materials Res"],"published-print":{"date-parts":[[2026,8]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Sepsis\u2010associated acute kidney injury (SA\u2010AKI) is a common and life\u2010threatening complication of sepsis, whose high incidence and mortality severely impair patient prognosis. Existing anti\u2010AKI drugs exhibit limited efficacy due to their inability to efficiently target injured kidneys. Although kidney\u2010targeted nanocarrier delivery systems show potential, exogenous nanoparticles are rapidly cleared by the immune system, resulting in a short blood circulatory half\u2010life and unsatisfactory targeting efficiency. Recombinant apolipoprotein H (rAPOH) exhibits anti\u2010apoptotic and anti\u2010inflammatory activities, holding promise for SA\u2010AKI treatment; however, its efficacy is constrained by insufficient targeting capability and rapid in\u00a0vivo metabolic clearance. In this study, we constructed a biomimetic delivery system (KMA@rAPOH) consisting of A@rAPOH nanoparticles coated with kidney\u2010targeting peptide\u2010functionalized renal tubular epithelial cell membranes to realize targeted rAPOH delivery for SA\u2010AKI therapy. The nanocarrier demonstrated satisfactory encapsulation efficiency, high drug loading capacity, and favorable controlled release, along with excellent long\u2010term stability in DMEM and deionized water. In\u00a0vitro, KMA@rAPOH was efficiently internalized by renal tubular epithelial cells and exerted significant anti\u2010apoptotic and anti\u2010inflammatory effects. In a mouse model of SA\u2010AKI, KMA@rAPOH markedly alleviated renal pathological damage and inhibited cell apoptosis. Additionally, it reduced the proportion of CD11c\n                    <jats:sup>+<\/jats:sup>\n                    F4\/80\n                    <jats:sup>+<\/jats:sup>\n                    pro\u2010inflammatory macrophages in the renal CD45\n                    <jats:sup>+<\/jats:sup>\n                    CD11b\n                    <jats:sup>+<\/jats:sup>\n                    population. Mechanistically, KMA@rAPOH was found to reduce TLR4 levels and inhibit NF\u2010\u03baB p65 phosphorylation, accompanied by decreased secretion of pro\u2010inflammatory cytokines including TNF\u2010\u03b1, IL\u20101\u03b2, and IL\u20106. These observations indicate that the TLR4\/NF\u2010\u03baB cascade may partially mediate the renoprotective activity of KMA@rAPOH, and this biomimetic nanoplatform represents a promising targeted delivery strategy for the treatment of renal inflammatory disorders.\n                  <\/jats:p>","DOI":"10.1002\/jbm.a.70143","type":"journal-article","created":{"date-parts":[[2026,8,11]],"date-time":"2026-08-11T15:44:55Z","timestamp":1786463095000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Kidney\u2010Targeted Biomimetic Nanoparticles Loaded With Apolipoprotein H Alleviate Sepsis\u2010Associated Acute Kidney Injury by Inhibiting the\n                    <scp>TLR4<\/scp>\n                    \/\n                    <scp>NF<\/scp>\n                    \u2010\n                    <scp>\u03baB<\/scp>\n                    Pathway"],"prefix":"10.1002","volume":"114","author":[{"given":"Lijun","family":"Zhu","sequence":"first","affiliation":[{"name":"Department of Anesthesiology Taizhou Hospital of Zhejiang Province Affiliated to Wenzhou Medical University  Taizhou Zhejiang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruyi","family":"He","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology Taizhou Hospital of Zhejiang Province Affiliated to Wenzhou Medical University  Taizhou Zhejiang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jincong","family":"Xiao","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology Taizhou Hospital of Zhejiang Province Affiliated to Wenzhou Medical University  Taizhou Zhejiang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2706-922X","authenticated-orcid":false,"given":"Guoqiang","family":"Hu","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology Taizhou Hospital of Zhejiang Province Affiliated to Wenzhou Medical University  Taizhou Zhejiang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kuangzhang","family":"You","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology Linhai First People's Hospital  Linhai Zhejiang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Suhuan","family":"Rao","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology Taizhou Hospital of Zhejiang Province Affiliated to Wenzhou Medical University  Taizhou Zhejiang 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