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Under inflammation, hypoxia occurs in tissues and under hypoxia, transcription factors induce overproduction of pro\u2010inflammatory cytokines, causing the chronic inflammatory process. There are very few studies that combine O\n                    <jats:sub>2<\/jats:sub>\n                    with anti\u2010inflammatory agents to simultaneously reduce the effects of hypoxia and inflammation. However, despite the important role of probiotic metabolites in regulating pro\u2010inflammatory cytokines, none of these studies have addressed the combined use of O\n                    <jats:sub>2<\/jats:sub>\n                    , anti\u2010inflammatory agents, and probiotic metabolites to effectively inhibit the harmful effects of hypoxia and inflammation. In this context, we report a biomaterial (GA\u2010\n                    <jats:sup>Rut<\/jats:sup>\n                    PMOF\u2010CAP) consisting of a GelMA\u2010Alginate (GA) hydrogel matrix incorporating rutin\u2010loaded, perfluorocarbon\u2010functionalized periodic mesoporous organosilica (\n                    <jats:sup>Rut<\/jats:sup>\n                    PMOF) nanoparticles and probiotic\u2010loaded alginate microcapsules (CAP), capable of delivering sustained O\n                    <jats:sub>2<\/jats:sub>\n                    , probiotic\u2010derived metabolites, and pH\u2010sensitive anti\u2010inflammatory drug release. GA\u2010\n                    <jats:sup>Rut<\/jats:sup>\n                    PMOF\u2010CAP, which provides approximately 90% release of the anti\u2010inflammatory drug (Rut) at pH\u20096.0, &gt;\u20095% O\n                    <jats:sub>2<\/jats:sub>\n                    release within the first 5\u2009days under hypoxic conditions, and release of probiotic metabolites over a 7\u2010day incubation period. GA\u2010\n                    <jats:sup>Rut<\/jats:sup>\n                    PMOF\u2010CAP does not increase the production of reactive oxygen species (ROS) during 1 and 7\u2009day incubation periods under hypoxic conditions. Furthermore, GA\u2010\n                    <jats:sup>Rut<\/jats:sup>\n                    PMOF\u2010CAP supports cell viability under hypoxia and promotes a decrease in TNF\u2010\u03b1 levels under LPS\u2010stimulated normoxic conditions; this demonstrates that GA\u2010\n                    <jats:sup>Rut<\/jats:sup>\n                    PMOF\u2010CAP has beneficial effects on cells under inflammatory\u2010like conditions.\n                  <\/jats:p>","DOI":"10.1002\/jbm.a.70150","type":"journal-article","created":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T10:04:28Z","timestamp":1790589868000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Generation of Probiotic\u2010Based Multifunctional Hydrogels Capable of Carrying Oxygen and Anti\u2010Inflammatory Drugs and Their Effect on Cell Viability Under Hypoxic Conditions"],"prefix":"10.1002","volume":"114","author":[{"ORCID":"https:\/\/orcid.org\/0009-0005-4800-2552","authenticated-orcid":false,"given":"Ulvi","family":"Suleymanzade","sequence":"first","affiliation":[{"name":"Department of Chemistry Izmir Institute of Technology  Urla\/Izmir T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ya\u011fmur Damla","family":"Demir","sequence":"additional","affiliation":[{"name":"Department of Chemistry Izmir Institute of Technology  Urla\/Izmir T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5347-7254","authenticated-orcid":false,"given":"Dilek","family":"Tepeli","sequence":"additional","affiliation":[{"name":"Department of Chemistry Izmir Institute of Technology  Urla\/Izmir T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-8454-607X","authenticated-orcid":false,"given":"Tu\u011fba Ezgi","family":"\u015eahin","sequence":"additional","affiliation":[{"name":"Department of Chemistry Izmir Institute of Technology  Urla\/Izmir T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2275-1254","authenticated-orcid":false,"given":"Nermin Seda","family":"Kehr","sequence":"additional","affiliation":[{"name":"Department of Chemistry Izmir Institute of Technology  Urla\/Izmir 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