{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T08:02:42Z","timestamp":1789459362374,"version":"build-2803163510"},"reference-count":40,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2026,9,4]],"date-time":"2026-09-04T00:00:00Z","timestamp":1788480000000},"content-version":"vor","delay-in-days":3,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Biomedical Materials Res"],"published-print":{"date-parts":[[2026,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Most cancer patients are at high risk of thrombotic complications. However, tumor therapy combined with thrombosis treatment is a challenge due to the discrepancy in the microenvironment between tumors and thrombosis. In this study, a nano polymer\u2010conjugate with tumor targeting and thrombolysis was developed. The nano polymer\u2010conjugate is formed by a cross\u2010linking agent containing imine bonds to cross\u2010link anti\u2010thrombosis drug nattokinase (NK) with a second\u2010generation dendrimer (G\n                    <jats:sub>2<\/jats:sub>\n                    ) in the outer layer (NK\u2010G\n                    <jats:sub>2<\/jats:sub>\n                    ), and magnetic silica is introduced during the cross\u2010linking. Then, a dual drug loading system (NK\u2010G\n                    <jats:sub>2<\/jats:sub>\n                    )\n                    <jats:sub>\n                      <jats:italic>n<\/jats:italic>\n                    <\/jats:sub>\n                    \/FA\u2010Dox is obtained by loading anti\u2010tumor drug doxorubicin (Dox) modified with folic acid (FA). FA and the magnetic silica enable the nano polymer\u2010conjugate to accumulate at the tumor sites. Most importantly, the nano polymer\u2010conjugate shows weak acid responsiveness, allowing it to dissociate in the tumor microenvironment and release two drugs without entering cancer cells. This addresses the problem of the discrepancy in the microenvironment between tumors and thrombosis. This dual\u2010drug loaded nano polymer\u2010conjugate exhibits excellent potential in the combined treatment of tumor and the thrombotic complications.\n                  <\/jats:p>","DOI":"10.1002\/jbm.a.70151","type":"journal-article","created":{"date-parts":[[2026,9,4]],"date-time":"2026-09-04T10:20:30Z","timestamp":1788517230000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Chemo\u2010Magnetic Targeted Dual\u2010Drug\u2010Loaded Nano Polymer\u2010Conjugate for Combined Tumor and Thrombosis Therapy"],"prefix":"10.1002","volume":"114","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1620-8063","authenticated-orcid":false,"given":"Shenglong","family":"Ding","sequence":"first","affiliation":[{"name":"College of Chemistry and Chemical Engineering, Lanzhou University  Lanzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mengjie","family":"Huang","sequence":"additional","affiliation":[{"name":"China Petroleum (Shanghai) New Materials Research Institute Co. 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