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Scaffolds are key to this goal, providing architecture, cell\u2010adhesion sites, and instructive cues required to organize cells into texturally mimetic tissue. To date, CM scaffold research has largely borrowed from tissue engineering, which optimizes for therapeutic function and does not account for the constraints that define a food product: edibility, low cost, and large scale. Here, we review scalable scaffold materials and fabrication methods for structured CM through this food\u2010first lens. We identify relevant elements of the native muscle microenvironment and assess how these characteristics have been recapitulated. We then evaluate the major classes of scaffold materials, including those of synthetic, animal, plant, fungal, and microbial origin, as well as waste\u2010stream\u2010derived materials, and compare their biological suitability and scalability. We organize fabrication methods by the biological function they address: cell expansion, alignment, bulk structure, and multi\u2010material assembly, treating mass transport as a constraint that cuts across these methods rather than a separate function. Throughout, we emphasize that consumer perception of meat quality is driven by architecture rather than physiological function, and throughput and cost determine commercial viability. We conclude by identifying critical gaps that warrant scientific focus to bring structured CM to market.<\/jats:p>","DOI":"10.1002\/jbm.a.70162","type":"journal-article","created":{"date-parts":[[2026,9,19]],"date-time":"2026-09-19T12:19:57Z","timestamp":1789820397000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Scalable Scaffold Materials for Structured Cultivated Meat"],"prefix":"10.1002","volume":"114","author":[{"ORCID":"https:\/\/orcid.org\/0009-0009-9461-9034","authenticated-orcid":false,"given":"Alex S.","family":"Kermani","sequence":"first","affiliation":[{"name":"Department of Orthopaedic Surgery UC Davis Health  Sacramento California USA"},{"name":"Department of Materials Science and Engineering UC Davis  Davis California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-0614-4782","authenticated-orcid":false,"given":"Andrea C.","family":"Filler","sequence":"additional","affiliation":[{"name":"Department of Orthopaedic Surgery UC Davis Health  Sacramento California USA"},{"name":"Department of Biomedical Engineering UC Davis  Davis California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1673-3335","authenticated-orcid":false,"given":"J. 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